Department of Physiology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Pakistan.
Center for Precision Medicine, School of Medicine and School of Biomedical Sciences, Huaqiao University, Xiamen 361021, China.
Molecules. 2018 Apr 2;23(4):814. doi: 10.3390/molecules23040814.
Neurodegeneration is a progressive loss of neuronal cells in certain regions of the brain. Most of the neurodegenerative disorders (NDDs) share the communal characteristic such as damage or reduction of various cell types typically including astrocytes and microglial activity. Several compounds are being trialed to treat NDDs but they possess solitary symptomatic advantages along with copious side effects. The finding of more enthralling and captivating compounds to suspend and standstill the pathology of NDDs will be considered as a hallmark of present times. Phytochemicals possess the potential to alternate the synthetic line of therapy against NDDs. The present review explores the potential efficacy of plant-derived flavonoids against most common NDDs including Alzheimer's disease (AD) and Parkinson's disease (PD). Flavonoids are biologically active phytochemicals which possess potential pharmacological effects, including antiviral, anti-allergic, antiplatelet, anti-inflammatory, anti-tumor, anti-apoptotic and anti-oxidant effects and are able to attenuate the pathology of various NDDs through down-regulating the nitric oxide (NO) production, by reducing the tumor necrosis factor-α (TNF-α), by reducing the excitotoxicity of superoxide as well as acting as tyrosine kinase (TK) and monoamine oxidase (MAO) inhibiting enzyme.
神经退行性变是大脑某些区域神经元细胞的进行性丧失。大多数神经退行性疾病（NDDs）具有共同的特征，如各种细胞类型（通常包括星形胶质细胞和小胶质细胞）的损伤或减少。目前正在尝试几种化合物来治疗 NDDs，但它们仅具有单一的对症优势，同时伴有大量的副作用。发现更具吸引力和吸引力的化合物来阻止和阻止 NDDs 的病理学将被视为当今的标志。植物化学物质具有改变针对 NDDs 的合成治疗线的潜力。本综述探讨了植物来源的类黄酮对包括阿尔茨海默病（AD）和帕金森病（PD）在内的最常见 NDDs 的潜在疗效。类黄酮是具有潜在药理作用的生物活性植物化学物质，包括抗病毒、抗过敏、抗血小板、抗炎、抗肿瘤、抗细胞凋亡和抗氧化作用，能够通过下调一氧化氮（NO）的产生，减少肿瘤坏死因子-α（TNF-α），减少超氧化物的兴奋毒性，以及作为酪氨酸激酶（TK）和单胺氧化酶（MAO）抑制酶来减轻各种 NDDs 的病理学。
