Screening of sera and tumor extracts of cancer patients using a monoclonal antibody directed against human placental alkaline phosphatase.
作者信息
Van de Voorde A, de Groote G, de Waele P, de Broe M E, Pollet D, de Boever J, Vandekerckhove D, Fiers W
出版信息
Eur J Cancer Clin Oncol. 1985 Jan;21(1):65-71. doi: 10.1016/0277-5379(85)90202-0.
PMID:3882432
Abstract
A sensitive endogenous enzyme immunoassay involving an anti-human placental alkaline phosphatase (PLAP) monoclonal antibody was used in the screening of sera and tumor extracts of patients with various types of cancer. In sera of breast cancer patients an incidence of 5.2% was recorded. This value rose to 43% when tumor extracts were analyzed. For lung and bronchial cancers we found 11.2% seropositive patients. On several occasions a good correlation was observed between the PLAP determinations and the histopathological staging of tumor tissue.
摘要
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Screening of sera and tumor extracts of cancer patients using a monoclonal antibody directed against human placental alkaline phosphatase.
Eur J Cancer Clin Oncol. 1985 Jan;21(1):65-71. doi: 10.1016/0277-5379(85)90202-0.
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