在温度范围从 T = 288.15 K 到 308.15 K 下，研究了在 HO + DMF、HO + DMSO 和 HO + ACN 二元混合物中具有生物学意义的氨基酸 l-丝氨酸和 L-半胱氨酸的溶解度和分子间相互作用。
Exploring the solubility and intermolecular interactions of biologically significant amino acids l-serine and L-cysteine in binary mixtures of HO + DMF, HO + DMSO and HO + ACN in temperature range from T = 288.15 K to 308.15 K.
机构信息
Department of Chemistry, University of Kalyani, Kalyani 741235, Nadia, India; Department of Chemistry, JIS College of Engineering, Kalyani 741235, Nadia, India.
Department of Chemistry, University of Kalyani, Kalyani 741235, Nadia, India.
出版信息
Biophys Chem. 2024 Aug;311:107272. doi: 10.1016/j.bpc.2024.107272. Epub 2024 May 27.
In the presented work, a study on the solubility and intermolecular interactions of l-serine and L-cysteine was carried out in binary mixtures of HO + dimethylformamide (DMF), HO + dimethylsulfoxide (DMSO), and HO + acetonitrile (ACN) in the temperature range of T = 288.15 K to 308.15 K. l-serine exhibited the highest solubility in water, while L-cysteine was more soluble in water-DMF. The solvation process was assessed through standard Gibbs energy calculations, indicating the solvation stability order: water-ACN > water-DMSO > water-DMF for l-serine, and water-DMF > water-DMSO > water-ACN for L-cysteine. This study also explored the influence of these amino acids on solvent-solvent interactions, revealing changes in chemical entropies and self-association patterns within the binary solvent mixtures.
在本工作中，在温度范围为 T = 288.15 K 至 308.15 K 的 HO + 二甲基甲酰胺（DMF）、HO + 二甲基亚砜（DMSO）和 HO + 乙腈（ACN）的二元混合物中，对 l-丝氨酸和 L-半胱氨酸的溶解度和分子间相互作用进行了研究。l-丝氨酸在水中的溶解度最高，而 L-半胱氨酸在水-DMF 中的溶解度更高。通过标准吉布斯能量计算评估了溶剂化过程，表明 l-丝氨酸的溶剂化稳定性顺序为：水-ACN > 水-DMSO > 水-DMF，而 L-半胱氨酸的溶剂化稳定性顺序为：水-DMF > 水-DMSO > 水-ACN。本研究还探讨了这些氨基酸对溶剂-溶剂相互作用的影响，揭示了二元溶剂混合物中化学熵和自缔合模式的变化。
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