氢化可的松通过β-肾上腺素能受体远端的作用增加肥大细胞对β-肾上腺素能激动剂的反应性。
Hydrocortisone increases the responsiveness of mast cells to beta-adrenergic agonists by an action distal to the beta-adrenoreceptors.
作者信息
Tolone G, Bonasera L, Sajeva R
出版信息
Br J Exp Pathol. 1979 Jun;60(3):269-75.
Abstract
Hydrocortisone in pharmacologically attainable concentrations potentiates beta-adrenergic-stimulated cyclic AMP accumulation in rat peritoneal mast cells. Direct binding studies using 3H-dihydroalprenolol indicated no significant changes in the number of beta-adrenoreceptors or in the kinetics of the interaction of the radio-ligand with receptors after treatment of mast cells with the corticosteroid. Competition binding studies with epinephrine revealed no hydrocortisone-induced change in Kd values for this agonist. It is concluded that hydrocortisone-induced stimulation of cyclic AMP synthesis results from an effect that occurs beyond the interaction of the beta-adrenergic agonist with its receptor.
摘要
药理上可达到的浓度的氢化可的松可增强大鼠腹膜肥大细胞中β-肾上腺素能刺激的环磷酸腺苷（cAMP）积累。使用3H-二氢阿普洛尔的直接结合研究表明，在用皮质类固醇处理肥大细胞后，β-肾上腺素能受体的数量或放射性配体与受体相互作用的动力学没有显著变化。用肾上腺素进行的竞争结合研究显示，氢化可的松不会引起该激动剂的解离常数（Kd）值发生变化。得出的结论是，氢化可的松诱导的环磷酸腺苷合成刺激是由β-肾上腺素能激动剂与其受体相互作用之外的一种效应引起的。
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