肥大细胞对前列腺素的生物合成与释放
Biosynthesis and release of prostaglandins by mast cells.
作者信息
Tolone G, Bonasera L, Tolone C
出版信息
Br J Exp Pathol. 1978 Feb;59(1):105-9.
Abstract
Rat mast cells, isolated from peritoneal fluids, were found to release substantial amounts of immunoreactive E-type prostaglandin when stimulated in vitro by foetal calf serum or incubated in the presence of arachidonic acid. Extracellular accumulation of iPGE reflected synthesis, rather than release of preformed material, since it was abolished by indomethacin, a potent and relatively specific inhibitor of prostaglandin synthetase. Hydrocortisone and Compound 48/80, in such experimental conditions, did not affect PGE release.
摘要
从腹腔液中分离出的大鼠肥大细胞，在体外受胎牛血清刺激或在花生四烯酸存在下孵育时，会释放大量免疫反应性E型前列腺素。细胞外iPGE的积累反映了其合成过程，而非预先形成物质的释放，因为它被吲哚美辛（一种强效且相对特异的前列腺素合成酶抑制剂）所抑制。在这种实验条件下，氢化可的松和化合物48/80不影响PGE的释放。
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本文引用的文献
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Evidence for enzymatic histamine release from isolated rat mast cells.从分离的大鼠肥大细胞中酶促释放组胺的证据。
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Radioimmunoassay for prostaglandins.前列腺素的放射免疫测定法。
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Significance of phospholipase A for prostaglandin formation.磷脂酶A对前列腺素形成的意义。
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Prostaglandin production by mouse fibrosarcoma cells in culture: inhibition by indomethacin and aspirin.培养的小鼠纤维肉瘤细胞中前列腺素的产生：吲哚美辛和阿司匹林的抑制作用
Biochem Biophys Res Commun. 1972 May 26;47(4):888-96. doi: 10.1016/0006-291x(72)90576-1.
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Proceedings: Prostaglandin production by rabbit peritoneal polymorphonuclear leukocytes in vitro.论文：兔腹膜多形核白细胞体外前列腺素的产生
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Prostaglandins and lymphokines in arthritis.关节炎中的前列腺素和淋巴因子
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The release of spasmogenic substances from human chopped lung tissue and its inhibition.人肺组织匀浆中致痉物质的释放及其抑制作用
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