Otani T, Katami K, Osada Y
Infect Immun. 1985 Mar;47(3):767-73. doi: 10.1128/iai.47.3.767-773.1985.
The effects of staphylococcal enterotoxins A, B, and C2 (SEA, SEB, and SEC2) on the resistance of mice to microbial infections were studied. SEA stimulated the resistance strongly, whereas SEB and SEC2 had no such effect. Treatment with SEA increased the number of peripheral blood polymorphonuclear leukocytes significantly within 4 h, and these polymorphonuclear leukocytes exhibited a higher chemiluminescence response than those of the controls. Furthermore, a significant increase in spleen weight was also observed in mice treated with SEA, and histologically that increase was characterized by a proliferation of lymphoblast-like cells which were stained with antibody to mouse Thy-1 but not with antibody to mouse immunoglobulin G by indirect immunofluorescence. As expected from the above findings, the treatment of nude mice (nu/nu) with SEA failed to protect them against Escherichia coli infections, whereas treatment of heterozygous (nu/+) controls afforded such protection. This was in part supported by the fact that the chemiluminescence response of peripheral blood polymorphonuclear leukocytes was increased significantly by treatment with SEA in nu/+mice but not in nu/nu mice.
研究了葡萄球菌肠毒素A、B和C2（SEA、SEB和SEC2）对小鼠抵抗微生物感染的影响。SEA强烈刺激抵抗力，而SEB和SEC2则无此作用。用SEA处理4小时内可显著增加外周血多形核白细胞数量，且这些多形核白细胞比对照组表现出更高的化学发光反应。此外，在用SEA处理的小鼠中还观察到脾脏重量显著增加，组织学上该增加的特征是淋巴母细胞样细胞增殖，通过间接免疫荧光法，这些细胞用抗小鼠Thy-1抗体染色，但不用抗小鼠免疫球蛋白G抗体染色。正如从上述发现所预期的那样，用SEA处理裸鼠（nu/nu）不能保护它们免受大肠杆菌感染，而异合子（nu/+）对照组的处理则提供了这种保护。nu/+小鼠用SEA处理后外周血多形核白细胞的化学发光反应显著增加，而nu/nu小鼠则不然，这一事实部分支持了上述结论。
