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[内源性激素在近视发生发展中的作用及机制研究进展]

[Advances in the study of the role and mechanisms of endogenous hormones in the development of myopia].

作者信息

Xu X T, Zhou X T

机构信息

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.

State Key Laboratory of Ophthalmology, Optometry and Vision Science, Wenzhou Medical University; Research Unit of Myopia Basic Research and Clinical Prevention and Control, Chinese Academy of Medical Sciences, Wenzhou 325027, China.

出版信息

Zhonghua Yan Ke Za Zhi. 2024 Jun 11;60(6):547-558. doi: 10.3760/cma.j.cn112142-20231106-00213.

Abstract

With the increasing prevalence of myopia among adolescents, the pathogenesis of this condition has garnered significant attention. Studies have discovered the expression of various hormone receptors in ocular tissues of both animals and humans. Additionally, changes in hormone levels accompany the development of myopia, although the exact relationships remain inconclusive. This article reviews the potential influences and mechanisms of action of endogenous hormones such as melatonin, serotonin, insulin, glucagon, sex hormones, vitamin D, and prostaglandins in ocular tissues including the retina, choroid, and sclera. It elaborates on the relationship between fluctuations in these hormone levels and the progression of myopia, aiming to provide guidance for exploring targets for myopia prevention and control.

摘要

随着青少年近视患病率的不断上升,这种疾病的发病机制已引起广泛关注。研究发现,动物和人类的眼部组织中均存在多种激素受体的表达。此外,近视发展过程中伴随着激素水平的变化,尽管确切关系尚无定论。本文综述了褪黑素、血清素、胰岛素、胰高血糖素、性激素、维生素D和前列腺素等内源性激素对视网膜、脉络膜和巩膜等眼部组织的潜在影响及其作用机制。阐述了这些激素水平波动与近视进展之间的关系,旨在为探索近视防控靶点提供指导。

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