Bettmann M A, Higgins C B
Invest Radiol. 1985 Jan-Feb;20(1 Suppl):S70-4. doi: 10.1097/00004424-198501002-00017.
Ionic contrast agents currently used in cardiac angiography are well tolerated but have certain negative effects. In a five-center study of 273 patients undergoing cardiac catheterization, safety and efficacy of the new nonionic contrast agent, iohexol, were compared with that of the standard ionic material, sodium methylglucamine diatrizoate. Contrast injections were made into the left ventricle and left and right coronary arteries in all patients. Left ventricular, systemic arterial and pulmonary capillary wedge pressures, and electrocardiogram lead II were recorded for 2 minutes. Following the first right and first left coronary injection, systemic arterial pressure and electrocardiographic recordings were made for 1 minute. After each subsequent coronary injection, recordings were made for 20 seconds. Both agents were found to be safe and both provided good diagnostic information. Iohexol was seen to cause both less marked overall hemodynamic alterations and a lower incidence of significant changes in pressure and heart rate. Iohexol may have an important role in coronary angiography and left ventriculography, particularly in high-risk patients, because of its lesser effect on heart rate and blood pressure.
目前用于心脏血管造影的离子型造影剂耐受性良好，但有一定的负面影响。在一项针对273例接受心脏导管插入术患者的五中心研究中，将新型非离子型造影剂碘海醇的安全性和有效性与标准离子型材料泛影葡胺钠进行了比较。所有患者均向左心室及左右冠状动脉注射造影剂。记录左心室、体动脉和肺毛细血管楔压以及心电图II导联2分钟。在首次右冠状动脉和首次左冠状动脉注射后，记录体动脉压和心电图1分钟。每次随后的冠状动脉注射后，记录20秒。发现两种造影剂均安全，且均能提供良好的诊断信息。碘海醇引起的总体血液动力学改变不太明显，压力和心率显著变化的发生率也较低。由于碘海醇对心率和血压的影响较小，它在冠状动脉造影和左心室造影中可能具有重要作用，尤其是在高危患者中。
