Chacko Honey, Krishna C Vijay, Kuruvila Sheela
Dermatology, NMC Specialty Hospital, Abu Dhabi, ARE.
Dermatology, Thumbay University Hospital, Ajman, ARE.
Cureus. 2024 Apr 30;16(4):e59409. doi: 10.7759/cureus.59409. eCollection 2024 Apr.
Varicella infection in immunosuppressed adults can be severe with atypical presentation of skin lesions. Hemorrhagic and ecthymatous varicella is a rare entity and can be misdiagnosed due to its atypical presentation. In its severe form, individuals with underlying cell-mediated immunodeficiency disorders have a high risk of developing multiple organ involvement associated with varicella-zoster virus infection. Here, we report two cases of primary varicella with hemorrhagic and ecthymatous skin lesions in adults receiving systemic immunosuppressive drugs for autoimmune disorders. There are only a few case reports on hemorrhagic and ecthymatous varicella. Hence, this case report highlights the atypical presentation of varicella in immunosuppressed adults, which necessitates an early diagnosis and prompt treatment as a lifesaving step.
免疫抑制的成年人感染水痘可能很严重,皮肤病变表现不典型。出血性和脓疱性水痘是一种罕见的情况,因其不典型表现可能会被误诊。在其严重形式下,患有潜在细胞介导免疫缺陷疾病的个体发生与水痘-带状疱疹病毒感染相关的多器官受累的风险很高。在此,我们报告两例接受系统性免疫抑制药物治疗自身免疫性疾病的成年人原发性水痘伴出血性和脓疱性皮肤病变的病例。关于出血性和脓疱性水痘的病例报告很少。因此,本病例报告强调了免疫抑制成年人水痘的非典型表现,这需要早期诊断并及时治疗作为挽救生命之举。