Erhard H, Rünger T M, Kreienkamp M, Müller J, Müller-Hermelink H K, Bröcker E B
Department of Dermatology, University of Würzburg, Germany.
J Am Acad Dermatol. 1995 May;32(5 Pt 2):908-11. doi: 10.1016/0190-9622(95)91560-5.
We describe a patient with cutaneous T-cell lymphoma in whom persistent, painless, ecthymatous nodules developed as a result of a varicella-zoster virus infection. The localized infection occurred without a vesicular stage. Ultrastructural studies revealed a lack of epidermal involvement and massive varicella-zoster virus replication within endothelial cells, leading to an obliterative vasculitis. This suggests direct infection of dermal vessels from adjacent nerves, bypassing the epidermis, which is usually infected first in the classic infectious pathway during varicella-zoster virus reactivation from sensory nerves.
我们描述了一名皮肤T细胞淋巴瘤患者，其因水痘-带状疱疹病毒感染出现了持续的、无痛的深脓疱样结节。局部感染未经历水疱阶段。超微结构研究显示表皮未受累，内皮细胞内有大量水痘-带状疱疹病毒复制，导致闭塞性血管炎。这表明水痘-带状疱疹病毒从相邻神经直接感染真皮血管，绕过了表皮，而在水痘-带状疱疹病毒从感觉神经再激活的经典感染途径中，表皮通常首先被感染。
