Feighner J P, Cohn J B
J Clin Psychiatry. 1985 Mar;46(3 Pt 2):20-5.
Fluoxetine was compared to doxepin in geriatric out-patients with major depressive illness. At the end of the 6-week double-blind study, the mean endpoint scores for all rating scales were significantly improved over base-line in both treatment groups. A subsequent 48-week open-label study supported the finding that both drugs are efficacious for maintenance therapy in elderly depressed patients. Fluoxetine, which lacks anticholinergic effects and is nonsedating, was well-tolerated by most patients and had fewer total side effects than doxepin. Common drug-related side effects for fluoxetine included nervousness/anxiety and nausea. Common side effects of doxepin were dry mouth, drowsiness/sedation, constipation, and dizziness/lightheadedness.
在患有重度抑郁症的老年门诊患者中，对氟西汀和多塞平进行了比较。在为期6周的双盲研究结束时，两个治疗组所有评定量表的平均终点得分均较基线有显著改善。随后一项为期48周的开放标签研究支持了这一发现，即这两种药物对老年抑郁症患者的维持治疗均有效。氟西汀缺乏抗胆碱能作用且无镇静作用，大多数患者对其耐受性良好，与多塞平相比，总副作用更少。氟西汀常见的药物相关副作用包括紧张/焦虑和恶心。多塞平的常见副作用有口干、嗜睡/镇静、便秘以及头晕/眩晕。
