Stark P, Hardison C D
J Clin Psychiatry. 1985 Mar;46(3 Pt 2):53-8.
The efficacy of fluoxetine was evaluated in depressed patients in double-blind imipramine- and placebo-controlled clinical trials. Fluoxetine produced greater improvement than placebo on all major efficacy parameters and was comparable to imipramine with respect to the primary indicators of depression. Fluoxetine had significantly less associated anticholinergic effects, dizziness, drowsiness, somatosensory disturbance, and excessive sweating than imipramine. Although nausea occurred more frequently in fluoxetine patients, it was generally mild and well tolerated. A significantly smaller percentage of fluoxetine than imipramine patients terminated therapy because of adverse experiences.
在双盲、丙咪嗪和安慰剂对照的临床试验中，对抑郁症患者评估了氟西汀的疗效。在所有主要疗效参数方面，氟西汀比安慰剂产生了更大的改善，并且在抑郁症的主要指标方面与丙咪嗪相当。与丙咪嗪相比，氟西汀的抗胆碱能相关效应、头晕、嗜睡、躯体感觉障碍和多汗明显更少。尽管氟西汀治疗的患者恶心更频繁发生，但通常症状轻微且耐受性良好。因不良事件终止治疗的氟西汀患者比例明显低于丙咪嗪患者。
