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2型谱系的遗传多样性、进化及耐药性

Genetic diversity, evolution and drug resistance of lineage 2.

作者信息

Atavliyeva Sabina, Auganova Dana, Tarlykov Pavel

机构信息

Genomics and Proteomics Core Facility, National Center for Biotechnology, Astana, Kazakhstan.

出版信息

Front Microbiol. 2024 May 17;15:1384791. doi: 10.3389/fmicb.2024.1384791. eCollection 2024.

DOI:10.3389/fmicb.2024.1384791
PMID:38827149
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11140050/
Abstract

causes a chronic infectious disease called tuberculosis. Phylogenetic lineage 2 (L2) of , also known as the East Asian lineage, is associated with high virulence, increased transmissibility, and the spread of multidrug-resistant strains. This review article examines the genomic characteristics of the genome and lineage 2, such as the unique insertion sequence and spoligotype patterns, as well as MIRU-VNTR typing, and SNP-based barcoding. The review describes the geographical distribution of lineage 2 and its history of origin. In addition, the article discusses recent studies on drug resistance and compensatory mechanisms of lineage 2 and its impact on the pathogen's transmissibility and virulence. This review article discusses the importance of establishing a unified classification for lineage 2 to ensure consistency in terminology and criteria across different studies and settings.

摘要

会引发一种名为结核病的慢性传染病。结核分枝杆菌的系统发育谱系2（L2），也被称为东亚谱系，与高毒力、增强的传播性以及多重耐药菌株的传播有关。这篇综述文章研究了结核分枝杆菌基因组和谱系2的基因组特征，如独特的插入序列和间隔寡核苷酸分型模式，以及MIRU-VNTR分型和基于单核苷酸多态性的条形码技术。该综述描述了谱系2的地理分布及其起源历史。此外，文章还讨论了关于结核分枝杆菌谱系2的耐药性和补偿机制及其对病原体传播性和毒力影响的近期研究。这篇综述文章讨论了为谱系2建立统一分类的重要性，以确保不同研究和环境中术语和标准的一致性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7475/11140050/6feaceadf7fe/fmicb-15-1384791-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7475/11140050/15ae220738c9/fmicb-15-1384791-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7475/11140050/9400237e773a/fmicb-15-1384791-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7475/11140050/6a0763c644f6/fmicb-15-1384791-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7475/11140050/6feaceadf7fe/fmicb-15-1384791-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7475/11140050/15ae220738c9/fmicb-15-1384791-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7475/11140050/9400237e773a/fmicb-15-1384791-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7475/11140050/6a0763c644f6/fmicb-15-1384791-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7475/11140050/6feaceadf7fe/fmicb-15-1384791-g004.jpg

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Antibiotics (Basel). 2023 Dec 20;13(1):9. doi: 10.3390/antibiotics13010009.
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Genomic Characterization of Drug-Resistant L2/Beijing Isolates from Astana, Kazakhstan.来自哈萨克斯坦阿斯塔纳的耐多药L2/北京基因型菌株的基因组特征分析
Antibiotics (Basel). 2023 Oct 10;12(10):1523. doi: 10.3390/antibiotics12101523.
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Whole-Genome Sequence-Based Characterization of Pre-XDR Clinical Isolates Collected in Kazakhstan.
意大利各地收集的结核分枝杆菌菌株的全基因组测序综合数据集。
Sci Data. 2025 Apr 15;12(1):624. doi: 10.1038/s41597-025-04966-1.
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The chosen few: isolates for IMPAc-TB.精选少数菌：IMPAc-TB 的分离株。
Front Immunol. 2024 Oct 28;15:1427510. doi: 10.3389/fimmu.2024.1427510. eCollection 2024.
基于全基因组序列对哈萨克斯坦收集的准广泛耐药临床分离株的特征分析。
Diagnostics (Basel). 2023 Jun 8;13(12):2005. doi: 10.3390/diagnostics13122005.
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