• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

透明质酸注射后复发性眼睑水肿：病理生理机制及拟议的治疗方案

Post-Hyaluronic Acid Recurrent Eyelid Edema: Pathophysiologic Mechanisms and a Proposed Treatment Protocol.

作者信息

Karlin Justin, Vranis Neil, Dayan Erez, Parsa Kami

出版信息

Aesthet Surg J Open Forum. 2023 Dec 3;5:ojad102. doi: 10.1093/asjof/ojad102. eCollection 2023.

DOI:10.1093/asjof/ojad102
PMID:38828092
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11140515/
Abstract

BACKGROUND

Hyaluronic acid (HA) filler injections for facial augmentation are commonly administered but can lead to post-hyaluronic acid recurrent eyelid edema (PHAREE). The pathophysiology of this condition has not been fully understood.

OBJECTIVES

To report the successful treatment of PHAREE using serial hyaluronidase and fractionated radiofrequency microneedling, with additional carbon dioxide laser skin resurfacing in selected patients.

METHODS

Five patients with PHAREE were treated with serial hyaluronidase injections and fractionated radiofrequency microneedling, with 2 patients receiving carbon dioxide laser treatment. The patients were followed up for a minimum of 24 months.

RESULTS

All patients reported a resolution of PHAREE signs/symptoms with no adverse effects or recurrence. One patient demonstrated complete resolution after a single treatment; 4 required a series of treatments.

CONCLUSIONS

The proposed treatment protocol may provide advantages over hyaluronidase alone for PHAREE. The impermeable malar septum, vulnerable eyelid lymphatics, and potential immunogenicity of HA fragments likely contribute to PHAREE pathophysiology. Further research on pathophysiologic mechanisms is warranted.

摘要

背景

用于面部填充的透明质酸（HA）注射很常见，但可能导致透明质酸注射后复发性眼睑水肿（PHAREE）。这种情况的病理生理机制尚未完全明确。

目的

报告使用系列透明质酸酶和分次射频微针成功治疗PHAREE的情况，部分患者还额外接受了二氧化碳激光皮肤磨削术。

方法

对5例PHAREE患者进行了系列透明质酸酶注射和分次射频微针治疗，2例患者接受了二氧化碳激光治疗。对患者进行了至少24个月的随访。

结果

所有患者均报告PHAREE体征/症状消失，无不良反应或复发。1例患者单次治疗后完全缓解；4例需要一系列治疗。

结论

对于PHAREE，所提出的治疗方案可能比单独使用透明质酸酶更具优势。不可渗透的颧隔膜、脆弱的眼睑淋巴管以及HA片段潜在的免疫原性可能是PHAREE病理生理机制的原因。有必要对病理生理机制进行进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e782/11140515/1c787c15e9cd/ojad102f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e782/11140515/f44089652281/ojad102f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e782/11140515/202c5d9b182c/ojad102f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e782/11140515/8b19b46d22b4/ojad102f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e782/11140515/aba5d81ed72e/ojad102f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e782/11140515/94eea6b7f409/ojad102f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e782/11140515/ccc72f82e3ee/ojad102f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e782/11140515/a57d2e84bcb3/ojad102f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e782/11140515/1c787c15e9cd/ojad102f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e782/11140515/f44089652281/ojad102f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e782/11140515/202c5d9b182c/ojad102f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e782/11140515/8b19b46d22b4/ojad102f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e782/11140515/aba5d81ed72e/ojad102f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e782/11140515/94eea6b7f409/ojad102f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e782/11140515/ccc72f82e3ee/ojad102f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e782/11140515/a57d2e84bcb3/ojad102f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e782/11140515/1c787c15e9cd/ojad102f8.jpg

相似文献

1
Post-Hyaluronic Acid Recurrent Eyelid Edema: Pathophysiologic Mechanisms and a Proposed Treatment Protocol.透明质酸注射后复发性眼睑水肿：病理生理机制及拟议的治疗方案
Aesthet Surg J Open Forum. 2023 Dec 3;5:ojad102. doi: 10.1093/asjof/ojad102. eCollection 2023.
2
Late-onset periorbital edema in patients with a history of facial hyaluronic acid injection: A review on diagnosis and management.有面部透明质酸注射史患者的迟发性眶周水肿：诊断与治疗的综述。
J Plast Reconstr Aesthet Surg. 2024 Dec;99:271-279. doi: 10.1016/j.bjps.2024.09.061. Epub 2024 Sep 20.
3
Rehabilitation of the Dysmorphic Lower Eyelid From Hyaluronic Acid Filler: What to Do After a Good Periocular Treatment Goes Bad.透明质酸填充剂导致的畸形下眼睑修复：良好的眼周治疗效果不佳后该如何处理。
Aesthet Surg J. 2020 Jan 29;40(2):197-205. doi: 10.1093/asj/sjz078.
4
Managing Periocular Filler-Related Syndrome Prior to Lower Blepharoplasty.处理下眼睑整形术前的眼周填充物相关综合征。
Aesthetic Plast Surg. 2019 Feb;43(1):115-122. doi: 10.1007/s00266-018-1250-7. Epub 2018 Oct 8.
5
Hyaluronidase injection for the treatment of eyelid edema: a retrospective analysis of 20 patients.透明质酸酶注射治疗眼睑水肿：20 例患者的回顾性分析。
Eur J Med Res. 2014 May 28;19(1):30. doi: 10.1186/2047-783X-19-30.
6
Late-Onset Upper Eyelid and Brow Edema as a Long-Term Complication of Hyaluronic Acid Filler Injection.玻尿酸注射填充后长期发生的上眼睑和眉部水肿
Aesthet Surg J. 2021 May 18;41(6):NP464-NP471. doi: 10.1093/asj/sjaa126.
7
Chronic eyelid edema and xerophthalmia secondary to periorbital hyaluronic acid filler injection.慢性眼睑水肿和眶周透明质酸填充剂注射引起的干眼症。
J Cosmet Dermatol. 2020 Apr;19(4):824-826. doi: 10.1111/jocd.13111. Epub 2019 Aug 23.
8
A Scoping Review of Hyaluronidase Use in Managing the Complications of Aesthetic Interventions.透明质酸酶在处理美容干预并发症中的应用：范围综述
Aesthetic Plast Surg. 2024 Mar;48(6):1193-1209. doi: 10.1007/s00266-022-03207-9. Epub 2022 Dec 19.
9
Triamcinolone Injection in the Treatment of Malar Edema.曲安奈德注射液治疗颧部水肿
Dermatol Pract Concept. 2024 Apr 1;14(2):e2024117. doi: 10.5826/dpc.1402a117.
10
The duration of hyaluronidase and optimal timing of hyaluronic acid (HA) filler reinjection after hyaluronidase injection.透明质酸酶的作用持续时间以及透明质酸酶注射后透明质酸（HA）填充剂再次注射的最佳时机。
J Cosmet Laser Ther. 2018 Feb;20(1):52-57. doi: 10.1080/14764172.2017.1293825. Epub 2017 Dec 4.

引用本文的文献

1
Role of Hyaluronic Acid in Post-Blepharoplasty Volume Restoration and Complication Management: A Systematic Review.透明质酸在眼睑整形术后容积恢复及并发症管理中的作用：一项系统评价
J Clin Med. 2025 Jun 27;14(13):4572. doi: 10.3390/jcm14134572.

本文引用的文献

1
Tissue Filler Complications and Disasters.组织填充剂并发症与灾难
Plast Aesthet Nurs (Phila). 2022;42(4):175-177. doi: 10.1097/PSN.0000000000000464.
2
Soft Tissue Dermal Filler-Associated Necrosis and Impending Necrosis: A Systematic Review of the Literature.软组织真皮填充剂相关性坏死和即将发生的坏死：文献系统综述。
Dermatol Surg. 2022 Oct 1;48(10):1051-1056. doi: 10.1097/DSS.0000000000003574. Epub 2022 Sep 15.
3
Tissue Inflammatory Responses to Hyaluronic Acid Gel Filler.透明质酸凝胶填充剂的组织炎症反应
Dermatol Surg. 2022 Aug 1;48(8):885-887. doi: 10.1097/DSS.0000000000003505. Epub 2022 Jun 13.
4
Lipoteichoic acid and molecular weight of hyaluronic acid could explain the late inflammatory response trigger by hyaluronic acid fillers.脂磷壁酸和透明质酸的分子量可以解释透明质酸填充剂引发的迟发性炎症反应。
J Cosmet Dermatol. 2022 Nov;21(11):5610-5613. doi: 10.1111/jocd.15243. Epub 2022 Jul 27.
5
Aesthetic Plastic Surgery National Databank Statistics 2020-2021.2020 - 2021年美容整形外科学会国家数据库统计数据
Aesthet Surg J. 2022 Jun 22;42(Suppl 1):1-18. doi: 10.1093/asj/sjac116.
6
Soft tissue filler augmentation of the orbicularis retaining ligament to improve the lid-cheek junction.通过眼轮匝肌悬韧带的软组织填充来改善睑颊交界。
J Cosmet Dermatol. 2021 Nov;20(11):3446-3453. doi: 10.1111/jocd.14495. Epub 2021 Oct 22.
7
Blindness After Filler Injection: Mechanism and Treatment.填充物注射致盲：机制与治疗。
Facial Plast Surg Clin North Am. 2021 May;29(2):359-367. doi: 10.1016/j.fsc.2021.02.002. Epub 2021 Apr 24.
8
Treatment Options for Lower Eyelid Festoons.下眼睑袋状畸形的治疗选择。
Facial Plast Surg Clin North Am. 2021 May;29(2):301-309. doi: 10.1016/j.fsc.2021.02.005. Epub 2021 Apr 24.
9
The Rise and Fall of the Pale Puffy Lower Eyelid Pillow.下睑苍白肿胀眼袋的兴衰。
J Drugs Dermatol. 2021 Apr 1;20(4):475-476. doi: 10.36849/JDD.2021.5509.
10
Long-Term Patient Experience with Tetracycline Injections for Festoons.长期接受四环素注射治疗皮肤皱折的患者体验。
Plast Reconstr Surg. 2020 Dec;146(6):737e-743e. doi: 10.1097/PRS.0000000000007334.