Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.
University Cheikh Anta DIOP, Dakar, Senegal.
Parasit Vectors. 2018 Jul 3;11(1):387. doi: 10.1186/s13071-018-2948-8.
Co-infection of malaria and intestinal parasites is widespread in sub-Saharan Africa and causes severe disease especially among the poorest populations. It has been shown that an intestinal parasite (helminth), mixed intestinal helminth or Plasmodium parasite infection in a human induces a wide range of cytokine responses, including anti-inflammatory, pro-inflammatory as well as regulatory cytokines. Although immunological interactions have been suggested to occur during a concurrent infection of helminths and Plasmodium parasites, different conclusions have been drawn on the influence this co-infection has on cytokine production. This review briefly discusses patterns of selected cytokine (IL-6, IL-8, IL-10, TNF-α and INF-γ) responses associated with infections caused by Plasmodium, intestinal parasites as well as a Plasmodium-helminth co-infection.
疟疾和肠道寄生虫的合并感染在撒哈拉以南非洲很常见，尤其是在最贫困的人群中会导致严重疾病。研究表明，人类感染肠道寄生虫（蠕虫）、混合肠道蠕虫或疟原虫会引起广泛的细胞因子反应，包括抗炎、促炎和调节细胞因子。尽管已经表明在蠕虫和疟原虫的合并感染期间会发生免疫相互作用，但对于这种合并感染对细胞因子产生的影响得出了不同的结论。本文简要讨论了与疟原虫、肠道寄生虫以及疟原虫-蠕虫合并感染相关的选定细胞因子（IL-6、IL-8、IL-10、TNF-α和 IFN-γ）反应模式。
