Mahajan Hemant, Lieber Judith, Carson Mallinson Poppy Alice, Bhogadi Santhi, Banjara Santosh Kumar, Kinra Sanjay, Kulkarni Bharati
Indian Council of Medical Research - National Institute of Nutrition, Hyderabad, India.
London School of Hygiene & Tropical Medicine, London, UK.
Hum Nutr Metab. 2024 Jun;36:None. doi: 10.1016/j.hnm.2024.200254.
BACKGROUND & AIMS: Habitual dietary pattern has been shown to be a major modulator of systemic inflammation and is considered a modifiable risk factor for cardio-metabolic diseases (CMDs) and mental health disorders. We examined whether dietary-inflammation is associated with the multimorbidity of CMDs and mental health disorders in urbanizing-villages in southern India. We hypothesized that the participants with higher dietary-inflammation would have a higher burden of multimorbidity.
MATERIALS & METHODS: We conducted a cross-sectional analysis of 5984 adults (53% male) participating in the Andhra Pradesh Children and Parents' Study. We assessed dietary-inflammation using dietary inflammatory index (DII®) based on intake of 27 micro- and macro-nutrients which were measured using a validated food-frequency-questionnaires. The CMDs and mental health disorders were assessed using standardized clinical procedures and validated questionnaires. 'Multimorbidity' was defined as a co-existence of one or more CMDs (hypertension, diabetes, myocardial infarction, heart failure, angina and stroke) and one or more mental health disorders (depression and anxiety). The association of multimorbidity with dietary-inflammation was examined using robust Poisson regression.
The prevalence of multimorbidity was 3.5% and ∼75% of participants were consuming a pro-inflammatory diet (DII >0.0). As compared to the 1st DII-quartile (least dietary-inflammatory group), the adjusted prevalence ratio (95% confidence interval) for the presence of multimorbidity was 1.46(0.87, 2.46) for 2nd, 1.75(1.05, 2.89) for 3rd, and 1.77(1.06, 2.96) for 4th DII-quartile (p-trend = 0.021). There was no evidence of an interaction between DII and sex on multimorbidity.
Dietary-inflammation had a positive linear association with the multimorbidity, which suggest that even modest reduction in dietary-inflammation may reduce the multimorbidity burden.
习惯性饮食模式已被证明是全身炎症的主要调节因素，被认为是心血管代谢疾病（CMD）和心理健康障碍的一个可改变的风险因素。我们研究了饮食炎症是否与印度南部城市化村庄中CMD和心理健康障碍的多重疾病状态相关。我们假设饮食炎症较高的参与者多重疾病负担会更高。
我们对参与安得拉邦儿童与父母研究的5984名成年人（53%为男性）进行了横断面分析。我们使用饮食炎症指数（DII®）评估饮食炎症，该指数基于对27种微量和常量营养素的摄入量，这些营养素通过经过验证的食物频率问卷进行测量。CMD和心理健康障碍通过标准化临床程序和经过验证的问卷进行评估。“多重疾病状态”定义为一种或多种CMD（高血压、糖尿病、心肌梗死、心力衰竭、心绞痛和中风）和一种或多种心理健康障碍（抑郁症和焦虑症）并存。使用稳健泊松回归研究多重疾病状态与饮食炎症之间的关联。
多重疾病状态的患病率为3.5%，约75%的参与者食用促炎饮食（DII>0.0）。与第一DII四分位数（饮食炎症最少的组）相比，第二DII四分位数多重疾病状态的调整患病率比（95%置信区间）为1.46（0.87，2.46），第三为1.75（1.05，2.89），第四为1.77（1.06，2.96）（p趋势=0.021）。没有证据表明DII与性别在多重疾病状态上存在相互作用。
饮食炎症与多重疾病状态呈正线性关联，这表明即使适度降低饮食炎症也可能减轻多重疾病负担。
