Obstetric and Gynecologic Clinic, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
Second Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, School of Medicine, Aretaieion Hospital, Athens, Greece.
Front Endocrinol (Lausanne). 2024 May 17;15:1369248. doi: 10.3389/fendo.2024.1369248. eCollection 2024.
Reproduction ability requires a certain amount of body fat that is necessary for ovulation, menstruation and pregnancy. Fat tissue represents an endocrine organ with high metabolic activity as it produces adipokines such as leptin and adiponectin. Our aim is to examine potential associations between women of reproductive age's ovarian reserves and their levels of leptin and adiponectin.
74 women between 19 and 40 years of age consented to take part. Based on the patterns of their ovarian reserves, the women were divided into three main groups: women with adequate ovarian reserves (AOR - Group A, n=30), women with polycystic ovary syndrome (PCOS - Group B, n=31) and women with depleted ovarian reserves (DOR - Group C, n=13). Among these groups, several biochemical and demographic parameters were statistically compared.
Compared to the other two groups, women with DOR had statistically higher age and follicle stimulation hormone (FSH) levels. For estradiol (E2) and thyroid-stimulating hormone (TSH), no statistically significant difference was seen between the groups. In addition, women with PCOS had higher body mass index (BMI), luteinizing hormone (LH), total testosterone (TT), 17 hydroxyprogesterone (17-OHP), dehydroepiandrosterone (DHEA), anti-Mullerian hormone (AMH), and antral follicle count (AFC) than the other two groups. In line with expectations, women with DOR also had lower levels of AMH and AFC than the other two groups. Women with PCOS had higher leptin levels than the other two groups, but there was no statistically significant difference. Women with PCOS had lower levels of adiponectin than the other groups, however the difference was not statistically significant.
The way we classified women in our study according to their ovarian reserves is completely consistent with what has been published internationally. The ovarian reserve in women of reproductive age is not strongly correlated with leptin and adiponectin levels. For safe conclusions, more research including a greater number of samples is required.
生育能力需要一定量的体脂，这对于排卵、月经和怀孕是必要的。脂肪组织代表一种具有高代谢活性的内分泌器官，因为它会产生瘦素和脂联素等脂肪因子。我们的目的是检查生殖年龄妇女的卵巢储备与瘦素和脂联素水平之间的潜在关联。
74 名 19 至 40 岁的妇女同意参与。根据她们卵巢储备的模式，这些妇女被分为三个主要组：卵巢储备充足的妇女（AOR-组 A，n=30）、多囊卵巢综合征（PCOS-组 B，n=31）和卵巢储备枯竭的妇女（DOR-组 C，n=13）。在这些组中，对几个生化和人口统计学参数进行了统计学比较。
与其他两组相比，DOR 组的妇女年龄和卵泡刺激素（FSH）水平明显更高。对于雌二醇（E2）和促甲状腺激素（TSH），三组之间没有统计学差异。此外，PCOS 组的妇女体重指数（BMI）、黄体生成素（LH）、总睾酮（TT）、17 羟孕酮（17-OHP）、脱氢表雄酮（DHEA）、抗苗勒管激素（AMH）和窦卵泡计数（AFC）更高。与预期一致，DOR 组的妇女的 AMH 和 AFC 水平也低于其他两组。PCOS 组的妇女瘦素水平高于其他两组，但无统计学差异。PCOS 组的妇女脂联素水平低于其他两组，但无统计学意义。
我们根据卵巢储备情况对研究中的妇女进行分类的方法与国际上已发表的方法完全一致。生殖年龄妇女的卵巢储备与瘦素和脂联素水平没有很强的相关性。为了得出安全的结论，需要进行更多的研究，包括更多的样本。
