循环 kisspeptin 水平与育龄妇女卵巢储备功能之间是否存在关联？
Is There an Association Between Circulating Kisspeptin Levels and Ovarian Reserve in Women of Reproductive Age?
机构信息
Obstetric and Gynecologic Clinic, Medical School, Democritus University of Thrace, Alexandroupolis, Greece;
Second Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, School of Medicine, Aretaieion Hospital, Athens, Greece.
出版信息
In Vivo. 2023 Sep-Oct;37(5):2219-2223. doi: 10.21873/invivo.13322.
BACKGROUND/AIM: To investigate the possible association of kisspeptin levels with the ovarian reserves of women of reproductive age.
PATIENTS AND METHODS
Eighty women aged 19-40 participated after signing an informed consent. Of these, 74 were finally included as in 6 women the blood samples were considered inappropriate due to hemolysis. They were divided into three main groups according to their ovarian reserve patterns: women with adequate ovarian reserves (Group A - AOR) (n=30), women with increased ovarian reserves (Group B - PCOS) (n=31), and women with diminished ovarian reserves (Group C - DOR) (n=13).
RESULTS
Women with diminished ovarian reserves had statistically significantly increased age and FSH compared to the other two groups. No statistically significant difference was found between the three groups for estradiol and thyroid stimulating hormone. Moreover, body mass index, luteinizing hormone, total testosterone, 17-hydroxyprogesterone, dehydroepiandrosterone, anti-Mullerian hormone (AMH), and antral follicle count (AFC) were increased in group B compared to the other two groups. AMH and AFC were decreased in women with diminished ovarian reserves compared to the other two groups, as expected. The comparison of kisspeptin levels between the three groups showed that kisspeptin levels were increased in women with diminished ovarian reserves, compared to the other two groups, but without a statistically significant difference. However, kisspeptin levels in group C were statistically significantly higher than those in group A.
CONCLUSION
There are no strong indications that kisspeptin levels are associated with the ovarian reserve in women of reproductive age.
背景/目的：研究 kisspeptin 水平与生育期妇女卵巢储备功能之间可能存在的关联。
患者和方法
共有 80 名年龄在 19-40 岁的女性在签署知情同意书后参与了此项研究。其中，由于 6 名女性的血液样本存在溶血等问题，最终只有 74 名女性被纳入研究。根据卵巢储备模式，这些女性被分为三组：卵巢储备充足的女性（A 组 - AOR）（n=30）、卵巢储备增加的女性（B 组 - PCOS）（n=31）和卵巢储备减少的女性（C 组 - DOR）（n=13）。
结果
与其他两组相比，卵巢储备减少的女性年龄和 FSH 明显升高。三组间雌二醇和促甲状腺激素无统计学差异。此外，与其他两组相比，B 组的体重指数、黄体生成素、总睾酮、17-羟孕酮、脱氢表雄酮、抗苗勒管激素（AMH）和窦卵泡计数（AFC）增加。与其他两组相比，卵巢储备减少的女性 AMH 和 AFC 降低，这是意料之中的。三组间 kisspeptin 水平的比较显示，与其他两组相比，卵巢储备减少的女性 kisspeptin 水平升高，但无统计学差异。然而，C 组的 kisspeptin 水平明显高于 A 组。
结论
目前尚无强有力的证据表明 kisspeptin 水平与生育期妇女的卵巢储备功能有关。
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