Alblooshi Nouf Ali, Naseer Tiba Kahtan, Bijle Mohammed Nadeem
Department of Clinical Sciences, College of Dentistry, Ajman University, Ajman, United Arab Emirates.
Paediatric Dentistry, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.
Jpn Dent Sci Rev. 2024 Dec;60:154-162. doi: 10.1016/j.jdsr.2024.05.002. Epub 2024 May 22.
The scoping review objectives were to: 1) investigate the caries preventive potential of professionally deliverable fluoride (F)-containing agents with incorporated arginine (Arg); and 2) identify the future scope of research on Arg-F interventions for caries prevention. Of 150 identified records, 7 articles (6 investigations and 1 scoping review) were included for a complete review; with no clinical studies with/without appraisal. Arginine variants (L-Arg/Arg.HCl at 1% to 10% .) were examined for a potential professional application aimed at caries prevention, as reported with studies. Of the included articles, four studies explored L-Arg enriched 5% NaF varnish (Duraphat®) as a promising caries preventive agent, while only one considered incorporating L-Arg in MI varnish®/nanohydroxyapatite and one investigated glass ionomer cement for primary/secondary and tertiary caries prevention. The scoping review highlighted the scope for incorporating Arg to professionally deliverable F-containing agents. No clinical data are available to make conclusive recommendations about the caries preventive potential of professionally deliverable F-containing agents with incorporated Arg. With Arg-F varnish being investigated predominantly through studies, the data so far suggest that Arg was incorporated exclusively in Duraphat®, while the potential of Arg to prevent caries in other F-containing varnishes remains unexplored.
1）研究专业提供的含氟（F）并添加精氨酸（Arg）的制剂预防龋齿的潜力；2）确定未来关于Arg-F干预预防龋齿的研究范围。在150篇检索到的记录中，纳入了7篇文章（6项调查和1篇综述）进行全面审查；没有对有/无评估的临床研究进行审查。如研究报告所述，研究了精氨酸变体（1%至10%的L-Arg/Arg.HCl）在预防龋齿方面的潜在专业应用。在所纳入的文章中，四项研究探讨了富含5%L-Arg的氟化钠漆（Duraphat®）作为一种有前景的防龋剂，而只有一项研究考虑将L-Arg加入MI varnish®/纳米羟基磷灰石中，还有一项研究调查了玻璃离子水门汀用于预防乳牙/恒牙的一级、二级和三级龋齿。该综述强调了将Arg加入专业提供的含氟制剂的研究范围。目前尚无临床数据可就含Arg的专业提供的含氟制剂预防龋齿的潜力做出确凿推荐。由于对含Arg-F的漆主要是通过研究进行调查，目前的数据表明Arg仅被加入到Duraphat®中，而Arg在其他含氟漆中预防龋齿的潜力仍未得到探索。
