From the Department of Infectious Diseases and Clinical Microbiology (Uyar, Ak, Korkmaz, Mıstanoğlu Özatağ, Aslan); from the Department of Anesthesiology and Reanimation (Yıldız); from the Department of Medical Microbiology (Genç), Faculty of Medicine, Kütahya University of Health Sciences, Kütahya, from the Department of Infectious Diseases and Clinical Microbiology (Alkan), Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, and from the Department of Anesthesiology and Reanimation (Balcı), Faculty of Medicine, Ümraniye Education and Research Hospital, Istanbul, Turkey.
Saudi Med J. 2024 Jun;45(6):606-616. doi: 10.15537/smj.2024.45.6.20240102.
To assess the risk variables related to the types of candidemia for each patient, who was admitted into the intensive care unit regardless of the patient with or without complete diagnosis of COVID-19, during the period of March 2019 to December 2022.
The evaluation comparison of demographic and clinical data of COVID-19 positive and negative patients with candidemia confirmed in blood, 113 cases were assessed. Variables such as gender, age, age of hospitalization, history of hospitalization, concurrently infection, The acute physiology and chronic health evaluation-II scores, comorbidity checking, intubation, central venous catheter use, parenteral nutrition use, steroid use, antibiotic use, lymphopenia, and laboratory variables were evaluated. species distribution, antifungal susceptibility in blood culture were determined.
Coronavirus disease-19 was present in 62.8% of cases confirmed candidemia, and these cases were significantly different from COVID-19 negative cases. Significance was found in more intubation, central venous catheter use, parenteral nutrition, and steroid therapy in Group 2. There was no significance with species distribution and associated infection. In total, COVID-19 positive had higher hemoglobin, aspartate aminotransferase, alanine transaminase, and white blood cell levels, which may be associated with the possibility of revealing and controlling candidemia.
and () are the species seen in infected COVID-19 patients, while C. parapsilosis and are found in non-COVID-19 ones. Risk factors were intubation, parenteral nutrition, central venous catheter, and steroid in the COVID-19 group.
评估 2019 年 3 月至 2022 年 12 月期间，无论患者是否确诊 COVID-19，入住重症监护病房的患者中与各型念珠菌血症相关的风险变量。
对 113 例确诊为血液念珠菌血症的 COVID-19 阳性和阴性患者的人口统计学和临床数据进行评估比较。评估了性别、年龄、住院年龄、住院史、并发感染、急性生理学和慢性健康评估 II 评分、合并症检查、插管、中心静脉导管使用、肠外营养、皮质类固醇、抗生素、淋巴细胞减少和实验室变量等变量。确定了血培养中的菌种分布和抗真菌药敏性。
62.8%的确诊念珠菌血症病例存在 COVID-19，与 COVID-19 阴性病例存在显著差异。在第 2 组中，插管、中心静脉导管使用、肠外营养和皮质类固醇治疗的病例明显更多。在菌种分布和相关感染方面无显著差异。总的来说，COVID-19 阳性患者的血红蛋白、天门冬氨酸转氨酶、丙氨酸转氨酶和白细胞水平较高，这可能与揭示和控制念珠菌血症的可能性有关。
COVID-19 阳性患者感染的菌种为（），而非 COVID-19 患者感染的菌种为（）和（）。COVID-19 组的风险因素为插管、肠外营养、中心静脉导管和皮质类固醇。
