A Near-Infrared Fluorescent Probe with Large Stokes Shift for Sensitive Detection of Hydrogen Sulfide in Environmental Water, Food Spoilage, and Biological Systems.

Hydrogen sulfide (HS) is an important endogenous gas transmitter that plays a critical role in various physiological and pathological processes and can also cause a negative impact on foodstuffs. In this study, we designed and synthesized a simple, easily available, high-yield, and low-cost near-infrared (λ = 710 nm) fluorescent probe, , with a substantial Stokes shift (205 nm) for the detection of HS. features high selectivity and sensitivity (LOD = 80 nM) toward HS, accompanied by a noticeable color change. Upon interaction with HS, exhibits a restored ICT (Intramolecular Charge Transfer) process, thereby manifesting near-infrared fluorescence. has been successfully utilized to detect HS in actual water samples and to monitor the spoilage of food items, such as pork, shrimp, and eggs. Furthermore, enables the imaging of endogenous and exogenous HS in living MCF-7 cells and zebrafish. Hence, provides an attractive method for the detection of HS in environmental, food, and biological systems, holding potential value in physiological and pathological research.