Kolasiński Jerzy, Reysner Tomasz, Kolenda Małgorzata, Kołacz Szymon, Domagalska Małgorzata
Kolasinski Clinic, Hair Clinic Poznan, 62-020, Swarzędz, Poland.
Department of Palliative Medicine, Poznan University of Medical Sciences, 61-245, Poznań, Poland.
Perioper Med (Lond). 2024 Jun 3;13(1):52. doi: 10.1186/s13741-024-00406-7.
Tranexamic acid has been widely used in plastic surgery. However, its efficacy has yet to be fully established. This meta-analysis aimed to determine its effectiveness in aesthetic plastic surgery.
Following PRISMA guidelines, we conducted a meta-analysis of prospective randomised clinical trials that compared the effects of topical or systematic administration of tranexamic acid versus the control group in aesthetic plastic surgeries. The study was registered on the International Register of Systematic Reviews (PROSPERO) and is available online ( www.crd.york.uk/prospero , CRD42023492585).
Eleven studies encompassing 960 patients were included for the synthesis after critical evaluation. Systematic (MD - 18.05, 95% Cl, - 22.01, - 14.09, p < 0.00001) and topical (MD - 74.93, 95% Cl, - 88.79, - 61.07, p < 0.00001) administration of tranexamic acid reduced total blood loss. Topical tranexamic acid reduced drainage output (p < 0.0006).
Tranexamic acid reduced blood loss in aesthetic plastic surgery. More strictly defined RCTs, using high-quality methodology, are needed to evaluate the advantages and disadvantages of tranexamic acid in aesthetic plastic surgery.
氨甲环酸已在整形手术中广泛应用。然而，其疗效尚未完全确立。本荟萃分析旨在确定其在美容整形手术中的有效性。
按照PRISMA指南，我们对前瞻性随机临床试验进行了荟萃分析，这些试验比较了在美容整形手术中局部或全身应用氨甲环酸与对照组的效果。该研究已在国际系统评价注册库（PROSPERO）注册，可在线获取（www.crd.york.uk/prospero，CRD42023492585）。
经过严格评估，纳入了11项研究，共960例患者进行综合分析。全身应用（MD -18.05，95%CI，-22.01，-14.09，p<0.00001）和局部应用（MD -74.93，95%CI，-88.79，-61.07，p<0.00001）氨甲环酸均减少了总失血量。局部应用氨甲环酸减少了引流量（p<0.0006）。
氨甲环酸可减少美容整形手术中的失血量。需要采用更严格定义的随机对照试验和高质量方法来评估氨甲环酸在美容整形手术中的优缺点。
