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The role of O6-methylguanine-DNA methyltransferase in cell survival, mutagenesis and carcinogenesis.

作者信息

Yarosh D B

出版信息

Mutat Res. 1985 Jan-Mar;145(1-2):1-16. doi: 10.1016/0167-8817(85)90034-3.

DOI:10.1016/0167-8817(85)90034-3
PMID:3883145
Abstract
摘要

相似文献

1
The role of O6-methylguanine-DNA methyltransferase in cell survival, mutagenesis and carcinogenesis.
Mutat Res. 1985 Jan-Mar;145(1-2):1-16. doi: 10.1016/0167-8817(85)90034-3.
2
Methylation of the O6 position of guanine in DNA is the most likely initiating event in carcinogenesis by methylating agents.DNA中鸟嘌呤O6位的甲基化是甲基化剂致癌过程中最可能的起始事件。
Cancer Invest. 1984;2(3):223-31. doi: 10.3109/07357908409104376.
3
[Molecular mechanisms of the adaptive response to alkylating agents].[对烷化剂适应性反应的分子机制]
Biochimie. 1985 Oct-Nov;67(10-11):IX-XIV. doi: 10.1016/s0300-9084(85)80094-8.
4
Mutagenic frequencies of site-specifically located O6-methylguanine in wild-type Escherichia coli and in a strain deficient in ada-methyltransferase.野生型大肠杆菌和ada甲基转移酶缺陷菌株中位点特异性定位的O6-甲基鸟嘌呤的诱变频率。
J Bacteriol. 1991 Feb;173(3):1201-7. doi: 10.1128/jb.173.3.1201-1207.1991.
5
[Role of O6-methylguanine-DNA methyltransferase in repair of DNA damaged by alkylating agents].[O6-甲基鸟嘌呤-DNA甲基转移酶在烷基化剂所致DNA损伤修复中的作用]
Gan To Kagaku Ryoho. 1989 Mar;16(3 Pt 2):466-72.
6
Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents.哺乳动物O6-烷基鸟嘌呤-DNA烷基转移酶：对烷基化致癌剂和治疗剂反应中的调节及其重要性
Cancer Res. 1990 Oct 1;50(19):6119-29.
7
The contribution of O6-methylguanine and methylphosphotriesters to the cytotoxicity of alkylating agents in mammalian cells.O6-甲基鸟嘌呤和甲基磷酸三酯对烷化剂在哺乳动物细胞中细胞毒性的作用。
Carcinogenesis. 1988 Sep;9(9):1587-93. doi: 10.1093/carcin/9.9.1587.
8
Reduction of the toxicity and mutagenicity of alkylating agents in mammalian cells harboring the Escherichia coli alkyltransferase gene.在携带大肠杆菌烷基转移酶基因的哺乳动物细胞中降低烷化剂的毒性和致突变性。
Proc Natl Acad Sci U S A. 1986 Sep;83(17):6292-6. doi: 10.1073/pnas.83.17.6292.
9
Inhibition of human O6-methylguanine-DNA methyltransferase by 5-methylcytosine.5-甲基胞嘧啶对人O6-甲基鸟嘌呤-DNA甲基转移酶的抑制作用。
Cancer Res. 1994 Jan 15;54(2):327-9.
10
Cloning of the E. coli O6-methylguanine and methylphosphotriester methyltransferase gene using a functional DNA repair assay.利用功能性DNA修复检测法克隆大肠杆菌O6-甲基鸟嘌呤和甲基磷酸三酯甲基转移酶基因。
Nucleic Acids Res. 1985 Mar 25;13(6):1939-52. doi: 10.1093/nar/13.6.1939.

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Position-Dependent Effect of Guanine Base Damage and Mutations on Telomeric G-Quadruplex and Telomerase Extension.碱基位置对端粒 G-四链体和端粒酶延伸的鸟嘌呤碱基损伤和突变的影响
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BMC Cancer. 2010 Feb 2;10:30. doi: 10.1186/1471-2407-10-30.
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RASSF1A, BLU, NORE1A, PTEN and MGMT expression and promoter methylation in gliomas and glioma cell lines and evidence of deregulated expression of de novo DNMTs.RASSF1A、BLU、NORE1A、PTEN和MGMT在胶质瘤及胶质瘤细胞系中的表达与启动子甲基化以及从头DNMTs表达失调的证据
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Comparison of the genetic effects of equimolar doses of ENU and MNU: while the chemicals differ dramatically in their mutagenicity in stem-cell spermatogonia, both elicit very high mutation rates in differentiating spermatogonia.等摩尔剂量的ENU和MNU遗传效应比较：尽管这两种化学物质在干细胞精原细胞中的致突变性差异显著，但它们在分化中的精原细胞中均引发非常高的突变率。
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