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伴有（4；11）（q21；q23）易位的成人B细胞急性淋巴细胞白血病中的杯状核。

Cup-like nuclei in adult B-cell acute lymphoblastic leukemia with the translocation (4;11)(q21;q23).

作者信息

Lu Yuyang, Feng Xinran, Chen Fengyu

机构信息

Department of Clinical Laboratory, The People's Hospital of Wenshan Prefecture, Yunnan, China.

出版信息

Leuk Res Rep. 2024 May 18;21:100463. doi: 10.1016/j.lrr.2024.100463. eCollection 2024.

DOI:10.1016/j.lrr.2024.100463
PMID:38831789
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11144784/
Abstract

Cuplike Nuclei(CLN) cells, particularly rare in Acute Lymphoblastic Leukemia(ALL), have been documented in only few cases to date. A recent study has revealed a correlation between CLN and IKZF1 deletions in pediatric B-ALL. This study introduces a case of CLN in adult B-ALL with a translocation (4;11)(q21;q23), while discussing the current relevant literature on the subject. Through this examination, several unique characteristics of CLN cells in both ALL and Acute Myeloid Leukemia are highlighted. It is essential to accumulate further data to confirm these distinctive traits, and investigate the potential association between CLN and cytogenetic/molecular abnormalities.

摘要

杯状核（CLN）细胞在急性淋巴细胞白血病（ALL）中尤为罕见，迄今为止仅有少数病例有记录。最近一项研究揭示了儿童B-ALL中CLN与IKZF1缺失之间的相关性。本研究介绍了一例伴有（4；11）（q21；q23）易位的成人B-ALL中的CLN病例，同时讨论了目前关于该主题的相关文献。通过这项检查，突出了ALL和急性髓系白血病中CLN细胞的几个独特特征。积累更多数据以证实这些独特特征，并研究CLN与细胞遗传学/分子异常之间的潜在关联至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/557d/11144784/e0396762959e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/557d/11144784/23961984acf8/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/557d/11144784/e0396762959e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/557d/11144784/23961984acf8/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/557d/11144784/e0396762959e/gr2.jpg

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本文引用的文献

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Cuplike nuclei in B-cell acute lymphoblastic leukemia with DUX4 rearrangement.伴有DUX4重排的B细胞急性淋巴细胞白血病中的杯状核。
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