Liang Jinghao, Lin Yijian, Liu Yuanqing, Lin Hongmiao, Xie Zixian, Wu Tongtong, Zhang Xinrong, Zhou Xinyi, Tan Zhaofeng, Yin Weiqiang, Guo Zhihua
Department of Thoracic Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.
Second Clinical Medical College, Guangdong Medical University, Dongguan, 523000, China.
Heliyon. 2024 May 16;10(11):e31400. doi: 10.1016/j.heliyon.2024.e31400. eCollection 2024 Jun 15.
Recent research has reevaluated the traditional view of cancer's linear progression and recurrence by introducing cellular reprogramming a process in which cancer cells can their state under certain conditions. This change is driven by a combination of genetic and epigenetic factors, with pivotal roles played by key genes, and pathways, notably Wnt and Notch. The complexity of cancer's behavior is further influenced by factors such as the epithelial-mesenchymal transition (EMT) and therapy-induced stress, both of which are significant contributors to cancer recurrence. In this context bibliometric analysis emerges as a crucial tool for evaluating the impacts and trends within scientific literature. Our study utilized bibliometrics to analysis the role of cellular reprogramming oncology over the past two decades, highlighting its potential to improve cancer treatment outcomes. In conducting this analysis, we searched for literature search on cellular reprogramming (CR) in the Web of Science database, covering the years 2002-2022. We employed visualization tools like Citespace, VOSviewer, and Bibliometrix to analyze the collected data resulting in a dataset of 3102 articles. The United States and China emerged as leading contributors to this field, with the University of Texas MD Anderson Cancer Center being the most prolific institution. Menendez was the most influential scholar in this research domain. Cancers was the journal with the most publications on this subject. The most local-cited document was the article titled "Hallmarks of Cancer: The Next Generation". A comprehensive analysis has been conducted based on keywords and cited references. In recent years, the research emphasis has shifted to "extracellular vesicles," "cancer therapy," and "cellular plasticity". Therefore, this analysis uses bibliometrics to chart cutting-edge progress in cancer's cellular reprogramming, aiding experts to quickly understand and innovate in this crucial area.
最近的研究通过引入细胞重编程重新评估了癌症线性进展和复发的传统观点。细胞重编程是一个过程，在此过程中癌细胞在某些条件下可以改变其状态。这种变化是由遗传和表观遗传因素共同驱动的，关键基因和通路发挥着关键作用，尤其是Wnt和Notch通路。癌症行为的复杂性还受到上皮-间质转化（EMT）和治疗诱导应激等因素的进一步影响，这两者都是癌症复发的重要因素。在这种背景下，文献计量分析成为评估科学文献中的影响和趋势的关键工具。我们的研究利用文献计量学分析了过去二十年中细胞重编程在肿瘤学中的作用，突出了其改善癌症治疗结果的潜力。在进行这项分析时，我们在科学网数据库中搜索了关于细胞重编程（CR）的文献，涵盖2002年至2022年。我们使用了Citespace、VOSviewer和Bibliometrix等可视化工具来分析收集到的数据，得到了一个包含3102篇文章的数据集。美国和中国是该领域的主要贡献者，德克萨斯大学MD安德森癌症中心是产出最多的机构。梅嫩德斯是该研究领域最有影响力的学者。《Cancers》是关于该主题发表文章最多的期刊。被引用最多的文献是题为《癌症的标志：下一代》的文章。我们基于关键词和引用文献进行了全面分析。近年来，研究重点已转向“细胞外囊泡”“癌症治疗”和“细胞可塑性”。因此，本分析使用文献计量学来描绘癌症细胞重编程的前沿进展，帮助专家在这一关键领域快速理解并进行创新。
