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Synthetic Peptides Capable of Potent Multigroup Quorum Sensing Activation and Inhibition in Both Cultures and Biofilm Communities.
J Am Chem Soc. 2024 Jun 12;146(23):15941-15954. doi: 10.1021/jacs.4c02694. Epub 2024 Jun 4.
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Non-Native Peptides Capable of Pan-Activating the Quorum Sensing System across Multiple Specificity Groups of .
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Selective chemical inhibition of agr quorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistance.
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Simplified Autoinducing Peptide Mimetics with Single-Nanomolar Activity Against the Staphylococcus aureus AgrC Quorum Sensing Receptor.
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Competition/antagonism associations of biofilm formation among Staphylococcus epidermidis Agr groups I, II, and III.
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Conformational Switch to a β-Turn in a Staphylococcal Quorum Sensing Signal Peptide Causes a Dramatic Increase in Potency.
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Gut microbiome and its clinical implications: exploring the key players in human health.
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Chemical Modification of a Bacterial Siderophore by a Competitor in Dual-Species Biofilms.
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Microbiome and Human Health: Current Understanding, Engineering, and Enabling Technologies.
Chem Rev. 2023 Jan 11;123(1):31-72. doi: 10.1021/acs.chemrev.2c00431. Epub 2022 Nov 1.
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Staphylococcus epidermidis and its dual lifestyle in skin health and infection.
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Reconstitution of the quorum sensing pathway reveals a direct role for the integral membrane protease MroQ in pheromone biosynthesis.
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Signal Transduction Network Principles Underlying Bacterial Collective Behaviors.
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The Case against Antibiotics and for Anti-Virulence Therapeutics.
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