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减少术后麻醉处方默认药片计数的持续获益。

The persistent benefits of decreasing default pill counts for postoperative narcotic prescriptions.

机构信息

Department of Surgery, Yale School of Medicine, New Haven, Connecticut, United States of America.

Department of Surgery, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.

出版信息

PLoS One. 2024 Jun 4;19(6):e0304100. doi: 10.1371/journal.pone.0304100. eCollection 2024.

Abstract

BACKGROUND

In 2017, a university-based academic healthcare system changed the opioid default pill count from 30 to 12 pills. Modifying the electronic default pill count influences short-term clinician prescribing practices. We sought to understand the long-term impact on postoperative opioid prescribing habits after an opioid default pill count reduction.

MATERIALS AND METHODS

A retrospective electronic medical record system (EMRS) review was conducted in a healthcare system comprised of seven affiliated hospitals. Patients who underwent a surgical procedure and were prescribed an opioid on discharge between 2017-2021 were evaluated. All prescriptions were converted into morphine equivalents (MME). Analyses were performed with the chi-square test and Bonferonni adjusted t-test.

RESULTS

191,379 surgical procedures were studied. The average quantity of opioids prescribed decreased from 32 oxycodone 5 mg tablets in 2017 to 21 oxycodone 5 mg tablets in 2021 (236 MME to 154 MME, p<0.001). The percentage of patients obtaining a refill within 90 days of surgery varied between 18.3% and 19.9% (p<0.001). Patients with a pre-existing opioid prescription and opioid-naïve patients both had significant reductions in prescription quantities above the default MME (79.7% to 60.6% vs. 65.3% to 36.9%, p<0.001). There was no significant change in refills for both groups (pre-existing 36.7% to 38.3% (p = 0.1) vs naïve 15.0% to 15.3% (p = 0.29)).

CONCLUSIONS

The benefits of decreasing the default opioid pill count continue to accumulate long after the original change. Physician uptake of small changes to default EMRS practices represents a sustainable and effective intervention to reduce the quantities of postoperative opioids prescribed without deleterious effects on outpatient opiate requirements.

摘要

背景

2017 年,一个以大学为基础的学术医疗系统将阿片类药物的默认药丸计数从 30 片改为 12 片。修改电子默认药丸计数会影响短期临床医生的处方实践。我们旨在了解减少阿片类药物默认药丸计数后对术后阿片类药物处方习惯的长期影响。

材料和方法

在由七家附属医院组成的医疗系统中进行了回顾性电子病历系统 (EMRS) 审查。评估了 2017 年至 2021 年期间接受手术并出院时开具阿片类药物的患者。所有处方均转换为吗啡当量 (MME)。使用卡方检验和 Bonferroni 调整的 t 检验进行分析。

结果

研究了 191379 例手术。开具的阿片类药物数量从 2017 年的 32 片羟考酮 5 毫克片剂减少到 2021 年的 21 片羟考酮 5 毫克片剂(236 MME 至 154 MME,p<0.001)。术后 90 天内获得补药的患者比例在 18.3%至 19.9%之间(p<0.001)。有预先存在的阿片类药物处方和阿片类药物无经验的患者的处方数量都有明显减少,超过默认 MME(79.7%至 60.6%与 65.3%至 36.9%,p<0.001)。两组的补药量均无显著变化(预先存在的 36.7%至 38.3%(p = 0.1)与无经验的 15.0%至 15.3%(p = 0.29))。

结论

减少默认阿片类药物药丸计数的好处在最初改变后仍在不断积累。医生对默认 EMRS 实践的小改动的接受代表了一种可持续且有效的干预措施,可以减少术后开具的阿片类药物数量,而不会对门诊鸦片类药物需求产生不利影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b80e/11149874/f1ecb0b81dbf/pone.0304100.g001.jpg

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