Starling M B, Neutze J M, Hill D G, Jagusch M, Cleland J F, Johns A, Elliott R L
Prostaglandins Leukot Med. 1985 Jan;17(1):11-29. doi: 10.1016/0262-1746(85)90030-7.
Puppies 6-12 kg underwent cardiopulmonary bypass with profound hypothermia. Thirteen animals received 200 ng kg-1 min-1 of PGI2 during bypass whilst 11 control animals received equivalent volumes of glycine buffer (placebo) over a similar period. Results indicated preservation of platelets, leukocytes and fibrinogen levels, together with shortened activated partial thromboplastin times and fewer fibrinogen degradation products post-bypass in PGI2-treated animals. There was an initial fall in blood pressure and systemic vascular resistance in PGI2 treated animals, but pulmonary pressures and resistances, cardiac outputs, and heart rates showed no significant differences from controls. Higher and more satisfactory end of bypass and post-bypass blood pressure levels, together with a lesser fall-off in mean total pulmonary compliance, and shortened bypass times were achieved in treated animals. PGI2 appeared to afford some protection against lung damage as observed by histological studies. All beneficial effects appeared to be significantly greater amongst smaller animals. The results indicate possible benefits from the use of PGI2 in infant open heart surgery.
体重6 - 12千克的幼犬接受了深度低温体外循环。13只动物在体外循环期间接受200纳克/千克/分钟的前列环素（PGI2），而11只对照动物在相似时间段内接受等量的甘氨酸缓冲液（安慰剂）。结果表明，PGI2治疗组动物在体外循环后血小板、白细胞和纤维蛋白原水平得以保存，活化部分凝血活酶时间缩短，纤维蛋白原降解产物减少。PGI2治疗组动物血压和全身血管阻力最初有所下降，但肺压力和阻力、心输出量及心率与对照组无显著差异。治疗组动物在体外循环结束时及体外循环后的血压水平更高且更令人满意，平均总肺顺应性下降幅度较小，体外循环时间缩短。组织学研究表明，PGI2似乎对肺损伤有一定保护作用。所有有益效果在较小的动物中似乎更为显著。结果表明，在婴儿心脏直视手术中使用PGI2可能有益。
