Life Sciences Department, Barcelona Supercomputing Center (BSC), Jordi Girona, 29, 08034 Barcelona, Spain; Mechanisms of Disease Program, Institute for Research in Biomedicine (IRB), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Life Sciences Department, Barcelona Supercomputing Center (BSC), Jordi Girona, 29, 08034 Barcelona, Spain; Mechanisms of Disease Program, Institute for Research in Biomedicine (IRB), The Barcelona Institute of Science and Technology, Barcelona, Spain; ICREA, Pg. Lluis Companys 23, Barcelona 08010, Spain; Centro de Investigación Biomédica En Red de Enfermedades Infecciosas, Barcelona, Spain.
Curr Opin Microbiol. 2024 Aug;80:102491. doi: 10.1016/j.mib.2024.102491. Epub 2024 Jun 3.
Hybridisation is the crossing of two divergent lineages that give rise to offspring carrying an admixture of both parental genomes. Genome sequencing has revealed that this process is common in the Saccharomycotina, where a growing number of hybrid strains or species, including many pathogenic ones, have been recently described. Hybrids can display unique traits that may drive adaptation to new niches, and some pathogenic hybrids have been shown to have higher prevalence over their parents in human and environmental niches, suggesting a higher fitness and potential to colonise humans. Here, we discuss how hybridisation and its genomic and phenotypic outcomes can shape the evolution of fungal species and may play a role in the emergence of new pathogens.
杂交是指两个不同谱系的交叉，产生携带双亲基因组混合物的后代。基因组测序表明，这种过程在 Saccharomycotina 中很常见，最近描述了越来越多的杂交菌株或物种，包括许多病原体。杂种可以表现出独特的特征，这些特征可能有助于适应新的生态位，一些病原体杂种在人类和环境生态位中的流行程度高于其亲本，这表明它们具有更高的适应性和在人类中定植的潜力。在这里，我们讨论了杂交及其基因组和表型结果如何塑造真菌物种的进化，并可能在新病原体的出现中发挥作用。
