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杂交对一个非驯化真菌物种中转座元件积累的影响。

The effect of hybridization on transposable element accumulation in an undomesticated fungal species.

机构信息

Institut de Biologie Intégrative et des Systèmes (IBIS), Université Laval, Québec, Canada.

Département de biochimie, microbiologie et bioinformatique, Université Laval, Québec, Canada.

出版信息

Elife. 2020 Sep 21;9:e60474. doi: 10.7554/eLife.60474.

DOI:10.7554/eLife.60474
PMID:32955438
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7584455/
Abstract

Transposable elements (TEs) are mobile genetic elements that can profoundly impact the evolution of genomes and species. A long-standing hypothesis suggests that hybridization could deregulate TEs and trigger their accumulation, although it received mixed support from studies mostly in plants and animals. Here, we tested this hypothesis in fungi using incipient species of the undomesticated yeast . Population genomic data revealed no signature of higher transposition in natural hybrids. As we could not rule out the elimination of past transposition increase signatures by natural selection, we performed a laboratory evolution experiment on a panel of artificial hybrids to measure TE accumulation in the near absence of selection. Changes in TE copy numbers were not predicted by the level of evolutionary divergence between the parents of a hybrid genotype. Rather, they were highly dependent on the individual hybrid genotypes, showing that strong genotype-specific deterministic factors govern TE accumulation in yeast hybrids.

摘要

转座元件 (TEs) 是可移动的遗传元件，能够深刻影响基因组和物种的进化。一个长期存在的假说表明，杂交可能会使 TE 失去调控并触发其积累，尽管这一假说在植物和动物的研究中得到了不同程度的支持。在这里，我们使用未驯化酵母的初生种来检验真菌中的这一假说。群体基因组数据显示，自然杂交中没有 TE 转座增加的特征。由于我们不能排除自然选择消除过去 TE 转座增加的特征，因此我们在一组人工杂交种上进行了实验室进化实验，以在几乎没有选择的情况下测量 TE 的积累。TE 拷贝数的变化不能由杂交基因型亲本之间的进化分歧程度来预测。相反，它们高度依赖于个别杂交基因型，表明强的基因型特异性决定因素控制着酵母杂交种中 TE 的积累。

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