SGLT2 抑制剂和 GLP1 受体激动剂对动脉僵硬的影响：一项随机对照试验的荟萃分析。
The effect of SGLT2 inhibitors and GLP1 receptor agonists on arterial stiffness: A meta-analysis of randomized controlled trials.
机构信息
School of Health Sciences, University of Ioannina, Ioannina, Greece.
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.
出版信息
J Diabetes Complications. 2024 Jul;38(7):108781. doi: 10.1016/j.jdiacomp.2024.108781. Epub 2024 May 31.
BACKGROUND
Pulse wave velocity (PWV) and augmentation index (AIx) are indices used to assess arterial stiffness. We evaluated the effect of sodium glucose co-transporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP1-RA) on arterial stiffness indices.
METHODS
We searched PubMed (up to January 2024) for RCTs assessing the effect of SGLT2i or GLP1-RA on arterial stiffness with reporting outcomes PWV and AIx. Effect sizes of the included studies were expressed as weighted mean difference (WMD) and 95 % confidence interval. Subgroup analyses were performed based on comparator (placebo vs. active comparator), design (RCT vs. crossover), population (diabetic vs. all) and blindness (yes vs. no).
RESULTS
A total of 19 studies (SGLT2i, 12 studies; GLP1-RA, 5 studies; SGLT2i/GLP1-RA combination, 2 studies) assessing 1212 participants were included. We did not find any statistically significant association between GLP1-RA or SGLT2i and PWV or AIx. None of the subgroup analyses showed any statistically significant result.
CONCLUSION
No evidence of a favorable change in arterial stiffness indices (PWV, AIx) was found following the administration of SGLT2i or GLP1-RA.
背景
脉搏波速度（PWV）和增强指数（AIx）是用于评估动脉僵硬度的指标。我们评估了钠-葡萄糖共转运蛋白 2 抑制剂（SGLT2i）和胰高血糖素样肽-1 受体激动剂（GLP1-RA）对动脉僵硬度指标的影响。
方法
我们在 PubMed 上检索了截至 2024 年 1 月评估 SGLT2i 或 GLP1-RA 对 PWV 和 AIx 报告结局的动脉僵硬度影响的 RCT。纳入研究的效应量表示为加权均数差（WMD）和 95%置信区间。根据对照物（安慰剂与活性对照物）、设计（RCT 与交叉）、人群（糖尿病与所有）和盲法（是与否）进行亚组分析。
结果
共纳入 19 项研究（SGLT2i，12 项研究；GLP1-RA，5 项研究；SGLT2i/GLP1-RA 联合治疗，2 项研究），共纳入 1212 名参与者。我们未发现 GLP1-RA 或 SGLT2i 与 PWV 或 AIx 之间存在任何统计学上显著的关联。没有任何亚组分析显示出任何统计学上显著的结果。
结论
在给予 SGLT2i 或 GLP1-RA 后，未发现动脉僵硬度指标（PWV、AIx）有任何有利的变化。
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