Department of Graduate College, Hebei Medical University, Shijiazhuang 050011, China; Department of Hepatobiliary Surgery, Hebei General Hospital, Shijiazhuang 050051, China.
Department of Hepatobiliary Surgery, Hebei General Hospital, Shijiazhuang 050051, China.
Clin Imaging. 2024 Aug;112:110209. doi: 10.1016/j.clinimag.2024.110209. Epub 2024 May 31.
This meta-analysis aimed to compare the diagnostic effectiveness of [F]FDG PET/CT with that of [F]FDG PET/MRI in terms of identifying liver metastasis in patients with primary cancer.
PubMed, Embase, Web of Science, and the Cochrane Library were searched, and studies evaluating the diagnostic efficacy of [F]FDG PET/CT and [F]FDG PET/MRI in patients with liver metastasis of primary cancer were included. We used a random effects model to analyze their sensitivity and specificity. Subgroup analyses and corresponding meta-regressions focusing on race, image analysis, study design, and analysis methodologies were conducted. Cochrane Q and I statistics were used to assess intra-group and inter-group heterogeneity.
Seven articles with 343 patients were included in this meta-analysis. The sensitivity of [F]FDG PET/CT was 0.82 (95 % CI: 0.63-0.96), and that of [F]FDG PET/MRI was 0.91 (95 % CI: 0.82-0.98); there was no significant difference between the two methods (P = 0.32). Similarly, both methods showed equal specificity: 1.00 (95 % CI: 0.95-1.00) for [F]FDG PET/CT and 1.00 (95 % CI: 0.96-1.00) for [F]FDG PET/MRI, and thus, there was no significant difference between the methods (P = 0.41). Furthermore, the subgroup analyses revealed no differences. Meta-regression analysis revealed that race was a potential source of heterogeneity for [F]FDG PET/CT (P = 0.01), while image analysis and contrast agent were found to be potential sources of heterogeneity for [18F]FDG PET/MRI (P = 0.02).
[F]FDG PET/MRI has similar sensitivity and specificity to [F]FDG PET/CT for detecting liver metastasis of primary cancer in both the general population and in subgroups. [F]FDG PET/CT may be a more cost-effective option. However, the conclusions of this meta-analysis are tentative due to the limited number of studies included, and further research is necessary for validation.
本荟萃分析旨在比较 [F]FDG PET/CT 和 [F]FDG PET/MRI 在诊断原发性癌症肝转移方面的诊断效能。
检索 PubMed、Embase、Web of Science 和 Cochrane 图书馆，纳入评估 [F]FDG PET/CT 和 [F]FDG PET/MRI 对原发性癌症肝转移患者诊断效能的研究。采用随机效应模型分析其敏感度和特异度。针对种族、图像分析、研究设计和分析方法进行亚组分析和相应的元回归分析。采用 Cochrane Q 和 I 统计量评估组内和组间异质性。
纳入本荟萃分析的共有 7 项研究，涉及 343 例患者。[F]FDG PET/CT 的敏感度为 0.82（95%CI：0.63-0.96），[F]FDG PET/MRI 的敏感度为 0.91（95%CI：0.82-0.98），两者之间无显著差异（P=0.32）。同样，两种方法的特异度均相等：[F]FDG PET/CT 为 1.00（95%CI：0.95-1.00），[F]FDG PET/MRI 为 1.00（95%CI：0.96-1.00），两者之间亦无显著差异（P=0.41）。此外，亚组分析未显示出差异。元回归分析显示，种族是 [F]FDG PET/CT 异质性的一个潜在来源（P=0.01），而图像分析和对比剂是 [18F]FDG PET/MRI 异质性的潜在来源（P=0.02）。
在一般人群和亚组中，[F]FDG PET/MRI 诊断原发性癌症肝转移的敏感度和特异度与 [F]FDG PET/CT 相似。[F]FDG PET/CT 可能是一种更具成本效益的选择。但是，由于纳入的研究数量有限，本荟萃分析的结论尚不确定，需要进一步的研究来验证。
