Cardiovascular Department, Huzhou Traditional Chinese Medicine Hospital, Huzhou, China.
Cardiovascular Department, Huzhou Traditional Chinese Medicine Hospital, Huzhou, China.
Clin Imaging. 2024 Sep;113:110248. doi: 10.1016/j.clinimag.2024.110248. Epub 2024 Aug 2.
This meta-analysis aimed to evaluate the comparative diagnostic efficacy of [F]FDG PET/CT and [F]FDG PET/MRI in detecting cardiac sarcoidosis.
An extensive search was conducted in the PubMed and Embase databases to identify available publications up to November 2023. Studies were included if they evaluated the diagnostic efficacy of [F]FDG PET/CT and [F]FDG PET/MRI in patients with cardiac sarcoidosis. Sensitivity and specificity were evaluated using the DerSimonian and Laird method, with subsequent transformation via the Freeman-Tukey double inverse sine transformation. Publication bias was assessed using funnel plots and Egger's test.
16 articles involving 1361 patients were included in the meta-analysis. The overall sensitivity of [F]FDG PET/CT in detecting cardiac sarcoidosis was 0.77(95%CI: 0.62-0.89), while the overall sensitivity of [F]FDG PET/MRI was 0.94(95%CI: 0.84-1.00). The result indicated that [F]FDG PET/MRI appears to a higher sensitivity in comparison to [F]FDG PET/CT(P = 0.02). In contrast, the overall specificity of [F]FDG PET/CT in detecting cardiac sarcoidosis was 0.90(95%CI: 0.85-0.94), while the overall specificity of [F]FDG PET/MRI was 0.79(95%CI: 0.53-0.96), with no significant difference in specificity (P = 0.32).
Our meta-analysis indicates that [F]FDG PET/MRI demonstrates superior sensitivity and comparable specificity to [F]FDG PET/CT in detecting cardiac sarcoidosis. However, the small number of PET/MRI studies limited the evidence of current results. To validate these results, larger, prospective studies employing a head-to-head design are needed.
本荟萃分析旨在评估 [F]FDG PET/CT 和 [F]FDG PET/MRI 在诊断心肌结节病中的比较诊断效能。
在 PubMed 和 Embase 数据库中进行广泛检索，以确定截至 2023 年 11 月的可用文献。纳入评估 [F]FDG PET/CT 和 [F]FDG PET/MRI 在心肌结节病患者中的诊断效能的研究。使用 DerSimonian 和 Laird 方法评估敏感性和特异性，随后通过 Freeman-Tukey 双反正弦变换进行转换。使用漏斗图和 Egger 检验评估发表偏倚。
荟萃分析纳入了 16 项涉及 1361 名患者的研究。[F]FDG PET/CT 检测心肌结节病的总体敏感性为 0.77（95%CI：0.62-0.89），而 [F]FDG PET/MRI 的总体敏感性为 0.94（95%CI：0.84-1.00）。结果表明，[F]FDG PET/MRI 的敏感性高于 [F]FDG PET/CT（P=0.02）。相比之下，[F]FDG PET/CT 检测心肌结节病的总体特异性为 0.90（95%CI：0.85-0.94），而 [F]FDG PET/MRI 的总体特异性为 0.79（95%CI：0.53-0.96），特异性无显著差异（P=0.32）。
本荟萃分析表明，[F]FDG PET/MRI 在诊断心肌结节病方面的敏感性优于 [F]FDG PET/CT，特异性相当。然而，PET/MRI 研究数量较少限制了当前结果的证据。为了验证这些结果，需要进行更大的、前瞻性的、头对头设计的研究。
