染色体分离：Mps1 和 Dam1 争夺在动粒上结合共享的相互作用位点。
Chromosome segregation: Mps1 and Dam1 battle to bind a shared interaction site at the kinetochore.
机构信息
Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
出版信息
Curr Biol. 2024 Jun 3;34(11):R530-R533. doi: 10.1016/j.cub.2024.04.070.
Abstract
The attachment of kinetochores to spindle microtubules is highly regulated to ensure proper chromosome segregation. Three new studies identify an interaction hub at the kinetochore that integrates kinetochore attachment state with spindle checkpoint activity and kinetochore assembly.
摘要
着丝粒与纺锤体微管的附着受到高度调控，以确保染色体的正确分离。三项新研究确定了着丝粒上的一个相互作用中心，该中心将着丝粒的附着状态与纺锤体检查点活性和着丝粒组装整合在一起。
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