Immunopathology Lab, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore 632 014, Tamil Nadu, India.
Immunopathology Lab, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore 632 014, Tamil Nadu, India.
Life Sci. 2024 Aug 1;350:122766. doi: 10.1016/j.lfs.2024.122766. Epub 2024 Jun 2.
Psoriatic arthritis (PsA) is a chronic inflammatory arthropathy affecting the skin, entheses, and joints. Over the past decade, experimental evidence has revealed the activation of several immune cells and signaling cascades in modulating the pathophysiology of PsA. Recently, targeted therapies have been developed to combat the severity of disease. However, with diverse etiologies, flareups, and relapses, there has been an increased prevalence and mortality associated with PsA in recent years. Therefore, it is imperative to investigate new potential mediators and combination therapies to manage PsA pathogenesis. IL-21, an immunomodulatory cytokine, has pleiotropic effects on immune cells and the protein cascades involved in PsA pathogenesis. Recently, emerging evidence of increased IL-21 levels in patients with PsA has engendered much enthusiasm for its potential as a therapeutic target. Here, we unmasked IL-21 as a significant modulator of PsA pathogenesis and reviewed the comorbidities associated with the disease, further cataloging future therapeutic modalities to ameliorate PsA progression.
银屑病关节炎（PsA）是一种影响皮肤、肌腱和关节的慢性炎症性关节病。在过去的十年中，实验证据揭示了几种免疫细胞和信号级联的激活在调节 PsA 的病理生理学中的作用。最近，已经开发出靶向疗法来治疗疾病的严重程度。然而，由于病因、发作和复发的多样性，近年来与 PsA 相关的患病率和死亡率有所增加。因此，研究新的潜在介质和联合疗法来治疗 PsA 的发病机制势在必行。IL-21 是一种免疫调节细胞因子，对免疫细胞和涉及 PsA 发病机制的蛋白质级联具有多效性作用。最近，越来越多的证据表明，PsA 患者的 IL-21 水平升高，这激发了人们对其作为治疗靶点的极大兴趣。在这里，我们揭示了 IL-21 作为 PsA 发病机制的重要调节剂，并回顾了与该疾病相关的合并症，进一步列出了改善 PsA 进展的未来治疗方法。
