Nicolopoulos N, Mantidis A, Stathopoulos E, Papaodysseas S, Kouvaris J, Varveris H, Papavasiliou C
Radiother Oncol. 1985 Jan;3(1):23-5. doi: 10.1016/s0167-8140(85)80005-0.
This is a double-blind study in which 14 randomly selected patients treated for lung cancer by irradiation, were receiving indomethacin, while 14 patients treated also by irradiation served as controls. The purpose of the study was to investigate a possible protective effect of the drug in irradiation esophagitis. The esophagus was included in the irradiation field in all patients. Histologic findings of esophagitis were not different in the two groups. However, endoscopic esophagitis and symptomatology were milder in the patients who received indomethacin.
这是一项双盲研究，14名随机挑选的接受放射治疗的肺癌患者正在服用吲哚美辛，而另外14名同样接受放射治疗的患者作为对照。该研究的目的是调查该药物对放射性食管炎是否可能具有保护作用。所有患者的食管均在放射野内。两组食管炎的组织学表现并无差异。然而，接受吲哚美辛治疗的患者内镜下食管炎及症状较轻。
