Medical Affairs Section, Research and Development Division, KM Biologics Co., Ltd., 1-6-1 Okubo, Kita-ku, Kumamoto-shi, Kumamoto, Japan.
Department of Surgery, Munakata Medical Association Hospital, Fukuoka, Japan.
Sci Rep. 2024 Jun 4;14(1):12773. doi: 10.1038/s41598-024-63682-9.
The use of fibrin glue for inguinal hernia mesh fixation has been suggested to be effective in preventing hematomas and reducing postoperative pain compared to tacks and sutures.. The effect of fibrin glue can vary significantly based on the device used. This study assessed the efficacy of fibrin glue based on the type of devices used in an ex vivo system. The rabbit's abdominal wall was trimmed to a size of 3.0 × 6.0 cm and was secured at the edges with metal fixtures. To measure the maximum tensile strength at the point of adhesion failure, the hernia mesh was fixed to the rabbit's abdominal wall using fibrin glue in a 2 cm square area, left for 3 min, and then pulled at a speed of 50 cm/min. The test was conducted 10 times for each group. The median (minimum-maximum) tensile strength values using the spraying, two-liquid mixing, and sequential layering methods were 3.58 (1.99-4.95), 0.51 (0.27-1.89), and 1.32 (0.63-1.66) N, respectively. The spraying method had predominantly higher tensile strength values than the two-liquid mixing and sequential layering methods (P < 0.01). In conclusion, in hernia mesh fixation, the spraying method can be adopted to achieve appropriate adhesive effects.
纤维蛋白胶在腹股沟疝补片固定中的应用，与钉合和缝合相比，被认为可以有效地预防血肿并减轻术后疼痛。纤维蛋白胶的效果可能因使用的器械而有很大差异。本研究在离体系统中评估了基于器械类型的纤维蛋白胶的疗效。将兔子的腹壁修剪至 3.0×6.0 cm 的大小，并在边缘用金属夹具固定。为了测量粘连失效点的最大拉伸强度，使用纤维蛋白胶将疝补片固定在兔子的腹壁上，面积为 2cm 见方，放置 3 分钟，然后以 50cm/min 的速度拉动。每个组进行了 10 次测试。使用喷涂、双液混合和顺序分层方法的拉伸强度中位数（最小值-最大值）分别为 3.58（1.99-4.95）、0.51（0.27-1.89）和 1.32（0.63-1.66）N。喷涂法的拉伸强度值明显高于双液混合法和顺序分层法（P<0.01）。总之，在疝补片固定中，可以采用喷涂法来达到适当的粘合效果。
