Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
University of Melbourne, Parkville, VIC, Australia.
Cell Death Differ. 2024 Jul;31(7):833-835. doi: 10.1038/s41418-024-01318-1. Epub 2024 Jun 4.
A series of recent studies have established where the necroptosis machinery — RIPK1, RIPK3, MLKL, ZBP1 and Caspase-8 — occur and are activated in mouse and human tissues, and how ZBP1 splicing might regulate necroptosis. These studies highlight the importance of mapping necroptosis spatially to understand how pathway dysregulation can lead to disease.
最近的一系列研究已经确定了坏死性凋亡机制（RIPK1、RIPK3、MLKL、ZBP1 和 Caspase-8）在小鼠和人类组织中发生和激活的位置，以及 ZBP1 剪接如何调节坏死性凋亡。这些研究强调了对坏死性凋亡进行空间定位的重要性，以了解途径失调如何导致疾病。
