Wang Qiaoye, Schmidt Amand Floriaan, Lennon Lucy T, Papacosta Olia, Whincup Peter H, Wannamethee Goya
Department of Primary Care and Population Health, Institute of Epidemiology and Health Care, University College London, London, UK.
Department of Population Science and Experimental Medicine, Institute of Cardiovascular Science, University College London, London, UK.
Commun Med (Lond). 2024 Jun 4;4(1):104. doi: 10.1038/s43856-024-00534-7.
Cardiometabolic diseases (CMD), including myocardial infarction, stroke, and type 2 diabetes, are leading causes of disability and mortality globally, particularly for people at an older age. The impact of adhering to the Life's Simple 7 (LS7) on the number of years an individual will live without CMD in older adults remains less studied.
This study included a cohort of 2662 British men aged 60-79 years free of CMD at baseline from the British Regional Heart Study (BRHS). Each LS7 factor (BMI, blood pressure, blood glucose, total cholesterol, smoking, physical activity, and diet) was categorized as poor, intermediate, or ideal, and a composite LS7 adherence was determined by summing the number of LS7 ideal levels achieved. Flexible parametric Royston-Parmar proportional-hazards model was applied to estimate CMD-free life expectancy.
Here we show that compared to men with the lowest LS7 adherence [with 18.42 years (95% CI: 16.93, 19.90) of CMD-free life at age 60], men having an ideal LS7 adherence are estimated to gain an additional 4.37 years (95% CI: 2.95, 5.79) of CMD-free life. The CMD-free life gain benefits are consistent across social class groups of manual and non-manual workers. Among LS7 factors, achieving an ideal physical activity provides the largest CMD-free survival benefit: 4.84 years (95% CI: 3.37, 6.32) of additional CMD-free life compared with the physically inactive group.
Our study quantifies and highlights the benefits of adhering to the LS7 ideal levels for living a longer life without CMD in older adults.
心脏代谢疾病（CMD），包括心肌梗死、中风和2型糖尿病，是全球致残和致死的主要原因，尤其是在老年人中。坚持“生命简单七法则”（LS7）对老年人无CMD生存年限的影响仍鲜少研究。
本研究纳入了英国地区心脏研究（BRHS）中2662名60 - 79岁基线时无CMD的英国男性队列。每个LS7因素（体重指数、血压、血糖、总胆固醇、吸烟、身体活动和饮食）分为差、中等或理想，通过计算达到的LS7理想水平数量来确定综合LS7依从性。应用灵活参数化的Royston - Parmar比例风险模型来估计无CMD预期寿命。
我们发现，与LS7依从性最低的男性相比[60岁时无CMD的预期寿命为18.42年（95%置信区间：16.93，19.90）]，LS7依从性理想的男性预计可多获得4.37年（95%置信区间：2.95，5.79）的无CMD预期寿命。无CMD预期寿命增加的益处在手工艺工人和非手工艺工人的社会阶层群体中是一致的。在LS7因素中，达到理想的身体活动水平带来的无CMD生存益处最大：与身体不活动组相比，可多获得4.84年（95%置信区间：3.37，6.32）的无CMD预期寿命。
我们的研究量化并突出了坚持LS7理想水平对老年人在无CMD情况下延长寿命的益处。
