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使用8字套入缝合术修复二叶式主动脉瓣的长期疗效

Long-term outcome of bicuspid aortic valve repair using figure-of-8 hitch-up stitches.

作者信息

Xiang Fei, Chen Lin, Chemtob Raphaelle, Roselli Eric E, Unai Shinya, Vargo Patrick, Koprivanac Marijan, Gillinov A Marc, Blackstone Eugene H, Rajeswaran Jeevanantham, Firth Austin, Desai Milind Y, Griffin Brian, Kalahasti Vidyasagar, Svensson Lars G

机构信息

Department of Thoracic and Cardiovascular Surgery, Heart, Vascular & Thoracic Institute, Cleveland Clinic, Cleveland, Ohio.

Department of Thoracic and Cardiovascular Surgery, Nanjing First Hospital, Nanjing, China.

出版信息

JTCVS Tech. 2024 Jan 22;24:27-40. doi: 10.1016/j.xjtc.2024.01.012. eCollection 2024 Apr.

Abstract

OBJECTIVE

To maximize successful repair of bicuspid aortic valves by adding figure-of-8 hitch-up stitches at commissures.

METHODS

From 2000 to 2022, bicuspid aortic valve repair was performed on 1112 patients at Cleveland Clinic, with 367 patients receiving figure-of-8 hitch-up stitches along with classical techniques, including Cabrol suture, cusp plication, raphe resection, and valve-sparing root replacement. Operative outcomes, repair durability, and survival were assessed in the figure-of-8 hitch-up stitches cohort, and outcomes were compared among 195 balancing-score-matched patient pairs who underwent bicuspid aortic valve repair with and without figure-of-8 hitch-up stitches.

RESULTS

Patients who underwent bicuspid aortic valve repair with figure-of-8 stitches had an operative mortality of 0.3% (1 of 367) and in-hospital reoperation for aortic valve dysfunction of 1.1% (4 of 367). At 10 years, prevalence of severe aortic regurgitation was 8.6%, mean gradient 24 mm Hg, freedom from aortic valve reoperation 75%, and survival 98%. In matched cohorts, operative mortality was similar (0.51% vs 0%;  > .9) as were morbidities, including in-hospital reoperation due to aortic valve dysfunction (1.0% vs 1.5%;  > .9). Comparable long-term outcomes were observed at 10 years (prevalence of severe aortic regurgitation of 8.7% vs 5.0% [ = .11], mean gradient 18 vs 17 mm Hg [ = .40]; freedom from aortic valve reoperation 80% vs 81% [ = .73]; and survival 99.5% vs 94.6% [ = .18]).

CONCLUSIONS

Figure-of-8 hitch-up stitch is a safe bicuspid aortic valve repair technique. It increases the likelihood of a successful repair without increasing risk of cusp tear and achieves satisfactory long-term survival and durability when added to classical repair techniques.

摘要

目的

通过在瓣叶交界处添加8字缝合提升术来最大限度地成功修复二叶式主动脉瓣。

方法

2000年至2022年,克利夫兰诊所对1112例患者进行了二叶式主动脉瓣修复术,其中367例患者在采用经典技术(包括卡布罗尔缝合、瓣叶折叠术、瓣缝切除和保留瓣膜的根部置换术)的同时接受了8字缝合提升术。对8字缝合提升术队列的手术结果、修复耐久性和生存率进行了评估,并在195对通过平衡评分匹配的患者中比较了接受和未接受8字缝合提升术的二叶式主动脉瓣修复患者的结果。

结果

接受8字缝合二叶式主动脉瓣修复术的患者手术死亡率为0.3%(367例中的1例),因主动脉瓣功能障碍的院内再次手术率为1.1%(367例中的4例)。在10年时,严重主动脉瓣反流的发生率为8.6%,平均压差为24 mmHg,无需进行主动脉瓣再次手术的比例为75%,生存率为98%。在匹配队列中,手术死亡率相似(0.51%对0%;>.9),发病率也相似,包括因主动脉瓣功能障碍的院内再次手术率(1.0%对1.5%;>.9)。在10年时观察到了可比的长期结果(严重主动脉瓣反流的发生率为8.7%对5.0%[P = 0.11],平均压差为18对17 mmHg[P = 0.40];无需进行主动脉瓣再次手术的比例为80%对81%[P = 0.73];生存率为99.5%对94.6%[P = 0.18])。

结论

8字缝合提升术是一种安全的二叶式主动脉瓣修复技术。它增加了成功修复的可能性,而不会增加瓣叶撕裂的风险,并且在添加到经典修复技术时可实现令人满意的长期生存和耐久性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa15/11145234/152dc90dc25c/ga1.jpg

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