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保留主动脉瓣的主动脉根部再植入手术治疗二叶式和三叶式主动脉瓣的早期及长期结果

Early and long-term results of aortic valve sparing aortic root reimplantation surgery for bicuspid and tricuspid aortic valves.

作者信息

Karciauskas Dainius, Mizariene Vaida, Jakuska Povilas, Ereminiene Egle, Orda Paulius, Ordiene Rasa, Vaskelyte Jolanta Justina, Nedzelskiene Irena, Kinduris Sarunas, Benetis Rimantas

机构信息

Department of Cardiac, Thoracic and Vascular Surgery, Hospital of Lithuanian University of Health Sciences Kauno Klinikos, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.

Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.

出版信息

Perfusion. 2019 Sep;34(6):482-489. doi: 10.1177/0267659119831926. Epub 2019 Mar 1.

Abstract

INTRODUCTION

To evaluate early and long-term clinical outcomes following aortic valve sparing aortic root reimplantation surgery in patients with leaking bicuspid and tricuspid aortic valves.

METHODS

The study consisted of 92 consecutive adult patients (tricuspid aortic valve group = 63 and bicuspid aortic valve group = 29) who underwent aortic valve sparing aortic root reimplantation surgery with or without aortic cusp repair for dilatation of the aortic root and/or aortic valve regurgitation at our institution from April 2004 to October 2016. Clinical outcomes were investigated using Kaplan-Meier and log-rank tests between groups.

RESULTS

The follow-up was 100% complete with a mean time of 5.3 ± 3.3 years. The 30-day in-hospital mortality was 3.1% in tricuspid aortic valve group and 3.4% in bicuspid aortic valve group patients. The overall survival rates at 10 years did not differ between bicuspid aortic valve and tricuspid aortic valve patient groups (96.6 ± 3.3% vs. 90.3 ± 4.2%, p = 0.3). Freedom from recurrent aortic valve regurgitation (>2+) at 10 years was 90.5 ± 4.1% in tricuspid aortic valve group and 75.7 ± 8.7% in bicuspid aortic valve group (p = 0.06). Freedom from aortic valve reoperation at 10 years was 100% in tricuspid aortic valve group and 83.9 ± 7.4% in bicuspid aortic valve group (p = 0.002).

CONCLUSION

Aortic valve sparing aortic root reimplantation surgery is a safe and efficient technique, providing acceptable long-term survival with low rates of valve-related complications in both tricuspid aortic valve and bicuspid aortic valve patient groups. However, aortic valve reoperation rates at 10 years follow-up were higher in bicuspid aortic valve group patients compared to tricuspid aortic valve group patients.

摘要

引言

评估主动脉瓣保留主动脉根部再植入手术治疗二叶式和三叶式主动脉瓣反流患者的早期和长期临床结局。

方法

本研究纳入了92例连续的成年患者(三叶式主动脉瓣组 = 63例,二叶式主动脉瓣组 = 29例),这些患者于2004年4月至2016年10月在我院接受了主动脉瓣保留主动脉根部再植入手术,手术方式包括或不包括主动脉瓣叶修复,用于治疗主动脉根部扩张和/或主动脉瓣反流。采用Kaplan-Meier法和log-rank检验对两组患者的临床结局进行研究。

结果

随访率达100%,平均随访时间为5.3±3.3年。三叶式主动脉瓣组患者30天内住院死亡率为3.1%,二叶式主动脉瓣组患者为3.4%。二叶式主动脉瓣患者组和三叶式主动脉瓣患者组10年总生存率无差异(96.6±3.3%对90.3±4.2%,p = 0.3)。三叶式主动脉瓣组10年无复发性主动脉瓣反流(>2+)率为90.5±4.1%,二叶式主动脉瓣组为75.7±8.7%(p = 0.06)。三叶式主动脉瓣组10年无主动脉瓣再次手术率为100%,二叶式主动脉瓣组为83.9±7.4%(p = 0.002)。

结论

主动脉瓣保留主动脉根部再植入手术是一种安全有效的技术,在三叶式主动脉瓣和二叶式主动脉瓣患者组中均能提供可接受的长期生存率,且瓣膜相关并发症发生率较低。然而,与三叶式主动脉瓣组患者相比,二叶式主动脉瓣组患者在10年随访时的主动脉瓣再次手术率更高。

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