Huang Ying, Chu Chenling, Mai Yuanyuan, Zhao Yue, Cao Luxi, Ji Shuiyu, Zhu Bin, Shen Quanquan
School of Public Health, Hangzhou Medical College, Hangzhou, China.
Urology and Nephrology Center, Department of Nephrology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China.
Front Pharmacol. 2024 May 15;15:1347234. doi: 10.3389/fphar.2024.1347234. eCollection 2024.
Peritoneal dialysis is one of the renal replacement treatments for patients with end-stage renal disease. Peritoneal dialysis-related peritoneal fibrosis is a pathological change in peritoneal tissue of peritoneal dialysis patients with progressive, non-suppurative inflammation accompanied by fibrous tissue hyperplasia, resulting in damage to the original structure and function, leading to peritoneal function failure. Currently, there is no specific drug in the clinic. Therefore, it is necessary to find a drug with good effects and few adverse reactions. Astragalus membranaceus (AMS) is the dried root of the (Fisch.) Bge. AMS and its active ingredients play a significant role in anti-inflammation, anti-fibrosis, regulation of immune function and regulation of blood pressure. Studies have shown that it can alleviate peritoneal fibrosis by reducing inflammatory response, inhibiting oxidative stress, degrading extracellular matrix deposition, regulating apoptosis, and regulating Transforming Growth Factor-β. The author summarized the relationship between AMS and its active ingredients by referring to relevant literature at home and abroad, in order to provide some theoretical basis for further clinical research.
腹膜透析是终末期肾病患者的肾脏替代治疗方法之一。腹膜透析相关的腹膜纤维化是腹膜透析患者腹膜组织的一种病理变化，表现为进行性、非化脓性炎症，伴有纤维组织增生，导致原始结构和功能受损，进而导致腹膜功能衰竭。目前临床上尚无特效药物。因此，有必要寻找一种疗效好、不良反应少的药物。黄芪是豆科植物蒙古黄芪或膜荚黄芪的干燥根。黄芪及其活性成分在抗炎、抗纤维化、调节免疫功能和调节血压方面发挥着重要作用。研究表明，它可以通过减轻炎症反应、抑制氧化应激、降解细胞外基质沉积、调节细胞凋亡以及调节转化生长因子-β来缓解腹膜纤维化。作者通过查阅国内外相关文献，总结了黄芪及其活性成分之间的关系，以期为进一步的临床研究提供一些理论依据。
