Wei C I, Cohen M D, Swartz D D, Fernando S Y, Corbett M D
Toxicol Lett. 1985 Jan;24(1):111-6. doi: 10.1016/0378-4274(85)90148-1.
The mutagenicity of some monoaromatic hydroxamic acids was tested in the presence and absence of rat liver S-9 with Salmonella typhimurium tester strains TA98 and TA100. Of the five N-(chlorophenyl)-substituted hydroxamic acids and seven N-arylformohydroxamic acids tested, 2 of the first and 4 of the latter series were mutagenic to both strains upon metabolic activation. None of the four N-acetyl-type hydroxamic acids was mutagenic to either strain, even upon activation. Because some of the N-acetyl-derived hydroxamic acids were inactive, whereas the same aromatic nucleus possessing a formyl group displayed significant activity, a consideration of the nature of the aryl group in hydroxamic acid mutagenicity is important.
在有和没有大鼠肝脏S-9的情况下，使用鼠伤寒沙门氏菌测试菌株TA98和TA100对一些单芳族异羟肟酸的致突变性进行了测试。在所测试的5种N-（氯苯基）取代的异羟肟酸和7种N-芳基甲酰异羟肟酸中，前一系列中的2种和后一系列中的4种在代谢活化后对两种菌株均具有致突变性。4种N-乙酰基型异羟肟酸中的任何一种对两种菌株均无致突变性，即使在活化后也是如此。由于一些N-乙酰基衍生的异羟肟酸没有活性，而具有甲酰基的相同芳核显示出显著活性，因此考虑异羟肟酸致突变性中芳基的性质很重要。
