异羟肟酸对鼠伤寒沙门氏菌的致突变性。

Mutagenicity of hydroxamic acids for Salmonella typhimurium.

作者信息

Wang C Y

出版信息

Mutat Res. 1977 Sep;56(1):7-12. doi: 10.1016/0027-5107(77)90235-4.

Abstract

P-Butoxyphenylacethydroxamic acid, benzohydroxamic acid, salicylhydroxamic acid, 2-naphthohydroxamic acid, indole-2-carbohydroxamic acid and benzoylaminoacethydroxamic acid were synthesized, and their mutagenicity for Salmonella typhimurium strains TA98 and TA100 were determined. Except for p-butoxyphenylacethydroxamic acid, all the hydroxamic acids were mutagenic for both strains. The mutagenicity progressed in the following order: 2-naphthohydroxamic acid greater than benzohydroxamic acid and salicylhydroxamic acid greater than benzoylaminoacethydroxamic acid and indole-2-carbohydroxamic acid. The starting materials for the synthesis of these acids including hydroxylamine were not in themselves mutagenic for TA98 and TA100. Thus, while the mutagenicity may require the hydroxamic acid as a whole, the acyl group may determine the mutagenic potency.

摘要

合成了对丁氧基苯乙酰异羟肟酸、苯甲酰异羟肟酸、水杨酰异羟肟酸、2-萘甲酰异羟肟酸、吲哚-2-甲酰异羟肟酸和苯甲酰氨基乙酰异羟肟酸，并测定了它们对鼠伤寒沙门氏菌TA98和TA100菌株的致突变性。除对丁氧基苯乙酰异羟肟酸外，所有异羟肟酸对这两种菌株均具有致突变性。致突变性按以下顺序递增：2-萘甲酰异羟肟酸＞苯甲酰异羟肟酸和水杨酰异羟肟酸＞苯甲酰氨基乙酰异羟肟酸和吲哚-2-甲酰异羟肟酸。合成这些酸所用的起始原料（包括羟胺）本身对TA98和TA100不具有致突变性。因此，虽然致突变性可能需要整个异羟肟酸，但酰基可能决定致突变效力。