Wu Tianlong, Lin Zebin, Wang Chizhen, Liu Xia
Department of Geriatrics, Zhongshan Hospital Affiliated to Xiamen University, Xiamen, Fujian, China.
The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China.
Front Med (Lausanne). 2024 May 21;11:1396254. doi: 10.3389/fmed.2024.1396254. eCollection 2024.
The association between vitamin D and blood pressure in elderly patients with hypertension complicated by osteoporosis remains unclear. The objective of this study is to explore whether vitamin D deficiency contributes to elevated blood pressure in elderly individuals with both hypertension and osteoporosis.
This study represents a single-center retrospective observational investigation carried out at the Zhongshan Hospital Affiliated to Xiamen University. Ambulatory blood pressure, bone density, vitamin D levels, and additional laboratory parameters were collected upon admission. The association between vitamin D and ambulatory blood pressure outcomes was assessed using Spearman correlation tests and partial correlation analyses. The relationship between vitamin D and changes in blood pressure was analyzed through Generalized Additive Models, and threshold analysis was conducted to explore potential thresholds.
139 patients with newly diagnosed osteoporosis were consecutively included (mean age 73 years, 84.9% female). There is a negative correlation between 25-(OH) D3 and 24 h mean systolic blood pressure (mSBP), diurnal mSBP, nocturnal mSBP, maximum SBP, respectively. The results of the generalized additive model analysis show that there is a nonlinear relationship between 25-(OH) D3 and 24 h mSBP, diurnal mSBP, nocturnal mSBP, respectively. After determining the critical point of 25-(OH) D3 as 42 nmol/L, a segmented linear regression model was used to calculate the effect size and 95% confidence interval on both sides of the critical point. When 25-(OH) D3 is ≤42 nmol/L, it significantly negatively correlates with 24 h, diurnal, and nocturnal mean SBP. Conversely, when 25-(OH) D3 exceeds 42 nmol/L, there is no statistically significant association with 24 h, diurnal, or nocturnal mSBP.
There was a significant negative correlation between vitamin D levels and blood pressure levels in elderly patients with hypertension and osteoporosis.
老年高血压合并骨质疏松患者中维生素D与血压之间的关联尚不清楚。本研究的目的是探讨维生素D缺乏是否会导致老年高血压合并骨质疏松患者血压升高。
本研究是在厦门大学附属中山医院进行的一项单中心回顾性观察性调查。入院时收集动态血压、骨密度、维生素D水平及其他实验室参数。使用Spearman相关检验和偏相关分析评估维生素D与动态血压结果之间的关联。通过广义相加模型分析维生素D与血压变化之间的关系，并进行阈值分析以探索潜在阈值。
连续纳入139例新诊断的骨质疏松患者（平均年龄73岁，84.9%为女性）。25-(OH)D3分别与24小时平均收缩压（mSBP）、日间mSBP、夜间mSBP、最高SBP呈负相关。广义相加模型分析结果显示，25-(OH)D3分别与24小时mSBP、日间mSBP、夜间mSBP之间存在非线性关系。确定25-(OH)D3的临界点为42 nmol/L后，使用分段线性回归模型计算临界点两侧的效应量和95%置信区间。当25-(OH)D3≤42 nmol/L时，它与24小时、日间和夜间平均SBP显著负相关。相反，当25-(OH)D3超过42 nmol/L时，与24小时、日间或夜间mSBP无统计学显著关联。
老年高血压合并骨质疏松患者中维生素D水平与血压水平之间存在显著负相关。
