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饮食中摄入乳制品中的维生素 D 可降低骨质疏松症的风险。

Dietary Intake of Vitamin D from Dairy Products Reduces the Risk of Osteoporosis.

机构信息

School of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino (MC), Italy.

School of Pharmacy, University of Camerino, 62032 Camerino (MC), Italy.

出版信息

Nutrients. 2020 Jun 10;12(6):1743. doi: 10.3390/nu12061743.

Abstract

Vitamin D and calcium are important dietary compounds that affect bone mass, even if other minerals (potassium, zinc, etc.) and vitamins (A, C and K) are also involved. Vitamin D and certain minerals, in fact, play an important role in calcium homeostasis and calcium absorption. Hip fracture incidence is higher in Europe and the United States, where calcium is frequently included in the human diet; while the occurrence of these fractures is lower in developing countries, where diets are often poor in calcium. This condition is named the "calcium paradox", and may be partially explained by phosphate toxicity, which can negatively affect mineral metabolism. It is important to maintain correct dietary calcium-phosphate balance in order to have a healthy life, reducing the risk of osteoporotic fractures in older people. Vitamin D can also act as a hormone; vitamin D2 (ergocalciferol) is derived from the UV-B radiation of ergosterol, the natural vitamin D precursor detected in plants, fungi, and invertebrates. Vitamin D3 (cholecalciferol) is synthesized by sunlight exposure from 7-dehydrocholesterol, a precursor of cholesterol that can also act as provitamin D3. Dietary intake of vitamin D3 is essential when the skin is exposed for short periods to ultraviolet B light (UV-B), a category of invisible light rays such as UV-A and UV-C. This can be considered the usual situation in northern latitudes during the winter season, or the typical lifestyle for older people and/or for people with very white delicate skin. The actual recommended daily intake of dietary vitamin D is strictly correlated with age, ranging from 5 μg for infants, children, teenagers, and adults-including pregnant and lactating women-to 15 μg for people over 65 years.

摘要

维生素 D 和钙是影响骨量的重要膳食化合物,即使其他矿物质(钾、锌等)和维生素(A、C 和 K)也参与其中。维生素 D 和某些矿物质实际上在钙稳态和钙吸收中发挥着重要作用。欧洲和美国的髋部骨折发生率较高,这些地区的饮食中经常含有钙;而在发展中国家,这些骨折的发生率较低,这些地区的饮食往往缺乏钙。这种情况被称为“钙悖论”,其部分原因可能是磷酸盐毒性,它会对矿物质代谢产生负面影响。为了拥有健康的生活,减少老年人骨质疏松性骨折的风险,保持正确的膳食钙磷平衡非常重要。维生素 D 也可以作为一种激素;维生素 D2(麦角钙化醇)源自 UV-B 辐射麦角固醇,这是一种在植物、真菌和无脊椎动物中发现的天然维生素 D 前体。维生素 D3(胆钙化醇)是由胆固醇的前体 7-脱氢胆固醇在阳光照射下合成的,7-脱氢胆固醇本身也可以作为维生素 D3 的前体发挥作用。当皮肤短时间暴露在紫外线 B 光(UV-B)下时,饮食中摄入维生素 D3 是必不可少的,紫外线 B 光是一种不可见光线,如紫外线 A 和紫外线 C。这可以被认为是在冬季的北方地区的常见情况,或者是老年人和/或皮肤非常白皙娇嫩的人的典型生活方式。实际推荐的每日膳食维生素 D 摄入量严格与年龄相关,从婴儿、儿童、青少年和成年人(包括孕妇和哺乳期妇女)的 5μg 到 65 岁以上人群的 15μg 不等。

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