Department of Pharmacy, The Second Xiangya Hospital, Central South University, Institute of Clinical Pharmacy, Central South University, Changsha, China.
Department of Pharmacy, Traffic Hospital of Hunan Province, Changsha, China.
Front Cell Infect Microbiol. 2024 May 21;14:1380312. doi: 10.3389/fcimb.2024.1380312. eCollection 2024.
, one of the main pathogens that causes community-acquired pneumonia, can lead to , a condition characterized predominantly by severe pneumonia. This disease, caused by the bacterium , can quickly progress to critical pneumonia and is often associated with damage to multiple organs. As a result, it requires close attention in terms of clinical diagnosis and treatment. Omadacycline, a new type of tetracycline derivative belonging to the aminomethylcycline class of antibiotics, is a semi-synthetic compound derived from minocycline. Its key structural feature, the aminomethyl modification, allows omadacycline to overcome bacterial resistance and broadens its range of effectiveness against bacteria. Clinical studies have demonstrated that omadacycline is not metabolized in the body, and patients with hepatic and renal dysfunction do not need to adjust their dosage. This paper reports a case of successful treatment of with omadacycline in a patient who initially did not respond to empirical treatment with moxifloxacin. The patient also experienced electrolyte disturbance, as well as dysfunction in the liver and kidneys, delirium, and other related psychiatric symptoms.
肺炎支原体是引起社区获得性肺炎的主要病原体之一,可导致以严重肺炎为主要特征的疾病。这种由细菌引起的疾病可迅速进展为重症肺炎,常伴有多个器官损伤。因此,在临床诊断和治疗方面需要密切关注。奥马环素是一种新型的四环素衍生物,属于氨基甲基环素类抗生素,是从米诺环素衍生而来的半合成化合物。其关键结构特征——氨基甲基修饰,使奥马环素能够克服细菌耐药性,并扩大其对细菌的有效作用范围。临床研究表明,奥马环素在体内不被代谢,肝肾功能不全的患者无需调整剂量。本文报告了一例奥马环素成功治疗初始经验性莫西沙星治疗无效的肺炎支原体感染患者的病例。该患者还出现电解质紊乱、肝肾功能障碍、意识障碍和其他相关精神症状。