Grill V, Adamson U, Viklund M
Acta Med Scand. 1985;217(1):41-5. doi: 10.1111/j.0954-6820.1985.tb01632.x.
Previous glucose improves subsequent glucose tolerance (the Staub-Traugott effect) in normal man. We have investigated whether a small amount of glucose (5 g) given perorally 30 min before breakfast would improve postprandial hyperglycemia in type 2 diabetics (19 patients). Blood glucose was increased 30 min after glucose ingestion (from 7.6 +/- 0.4 to 8.7 +/- 0.4 mmol/l, p less than 0.001). Total glucose areas measured between the time of glucose ingestion and 180 min after breakfast were similar during test and control conditions (breakfast alone). Apparent differences between individuals with regard to the effects of previous glucose on hyperglycemia were further analyzed. Differences could not be explained by interexperimental variation since they persisted on repeated testing (3 patients). Differences were not correlated with age, sex, duration of diabetes, obesity, fasting blood glucose or the insulin responses evoked in the experiments. We conclude that a small amount of glucose before breakfast fails to ameliorate postprandial hyperglycemia in overt type 2 diabetics except in individual patients in whom, in turn, the effect is not directly related to insulin secretion.
先前摄入葡萄糖可改善正常人随后的糖耐量（斯陶布 - 特劳戈特效应）。我们研究了早餐前30分钟口服少量葡萄糖（5克）是否会改善2型糖尿病患者（19例）的餐后高血糖。摄入葡萄糖后30分钟血糖升高（从7.6±0.4毫摩尔/升升至8.7±0.4毫摩尔/升，p＜0.001）。在试验和对照条件下（仅早餐），从摄入葡萄糖之时至早餐后180分钟测得的总葡萄糖曲线下面积相似。进一步分析了个体之间先前摄入葡萄糖对高血糖影响的明显差异。这些差异不能用实验间变异来解释，因为在重复测试时差异仍然存在（3例患者）。差异与年龄、性别、糖尿病病程、肥胖、空腹血糖或实验中诱发的胰岛素反应均无相关性。我们得出结论，早餐前少量葡萄糖不能改善明显的2型糖尿病患者的餐后高血糖，除非在个别患者中，而这些患者的这种效应又与胰岛素分泌无直接关系。
