Amankwaah Akua F, Sayer R Drew, Wright Amy J, Chen Ningning, McCrory Megan A, Campbell Wayne W
Department of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA.
Department of Public Health Sciences, College of Health Science, California Baptist University, Riverside, CA 92504, USA.
Nutrients. 2017 Apr 2;9(4):352. doi: 10.3390/nu9040352.
Dietary protein and fiber independently influence insulin-mediated glucose control. However, potential additive effects are not well-known. Men and women ( = 20; age: 26 ± 5 years; body mass index: 26.1 ± 0.2 kg/m²; mean ± standard deviation) consumed normal protein and fiber (NPNF; NP = 12.5 g, NF = 2 g), normal protein and high fiber (NPHF; NP = 12.5 g, HF = 8 g), high protein and normal fiber (HPNF; HP = 25 g, NF = 2 g), or high protein and fiber (HPHF; HP = 25 g, HF = 8 g) breakfast treatments during four 2-week interventions in a randomized crossover fashion. On the last day of each intervention, meal tolerance tests were completed to assess postprandial (every 60 min for 240 min) serum glucose and insulin concentrations. Continuous glucose monitoring was used to measure 24-h interstitial glucose during five days of the second week of each intervention. Repeated-measures ANOVA was applied for data analyses. The HPHF treatment did not affect postprandial glucose and insulin responses or 24-h glucose total area under the curve (AUC). Higher fiber intake reduced 240-min insulin AUC. Doubling the amount of protein from 12.5 g to 25 g/meal and quadrupling fiber from 2 to 8 g/meal at breakfast was not an effective strategy for modulating insulin-mediated glucose responses in these young, overweight adults.
膳食蛋白质和纤维分别影响胰岛素介导的血糖控制。然而，其潜在的叠加效应尚不清楚。男性和女性（ = 20；年龄：26±5岁；体重指数：26.1±0.2 kg/m²；均值±标准差）在四项为期2周的干预中，以随机交叉方式接受正常蛋白质和纤维（NPNF；NP = 12.5克，NF = 2克）、正常蛋白质和高纤维（NPHF；NP = 12.5克，HF = 8克）、高蛋白和正常纤维（HPNF；HP = 25克，NF = 2克）或高蛋白和纤维（HPHF；HP = 25克，HF = 8克）的早餐处理。在每次干预的最后一天，完成餐耐量试验以评估餐后（每60分钟，共240分钟）血清葡萄糖和胰岛素浓度。在每次干预第二周的五天内，使用连续血糖监测来测量24小时组织间液葡萄糖。采用重复测量方差分析进行数据分析。HPHF处理不影响餐后葡萄糖和胰岛素反应或24小时葡萄糖曲线下总面积（AUC）。较高的纤维摄入量降低了240分钟胰岛素AUC。在这些年轻超重成年人中，早餐时将蛋白质摄入量从12.5克/餐加倍至25克/餐，并将纤维摄入量从2克/餐增至8克/餐的四倍，并非调节胰岛素介导的葡萄糖反应的有效策略。
