University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, U.S.A.
Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania, U.S.A.
Laryngoscope. 2024 Nov;134(11):4549-4556. doi: 10.1002/lary.31554. Epub 2024 Jun 4.
This study describes patient-reported outcome measures (PROMs) and associated factors in patients who underwent surgery for malignant parotid tumors (MPT).
This is a retrospective study of all surgically treated MPT patients in a multidisciplinary head and neck cancer (HNC) survivorship clinic (2017-2023). PROMs included University of Washington Quality of Life Questionnaire (UW-QOL), Eating Assessment Tool (EAT-10), Patient Health Questionnaire (PHQ-8), Generalized Anxiety Disorder (GAD-7), Neck Disability Index (NDI), and Insomnia Severity Index. Multivariable regression analysis was used to investigate clinical predictors associated with PROMs.
In 62 MPT patients, the prevalence of clinically relevant dysphagia symptoms (EAT-10), elevated symptoms of depression (PHQ-8), moderate/severe symptoms of anxiety (GAD-7), moderate/severe neck pain with activities of daily living (NDI), and moderate/severe symptoms of insomnia at last follow-up was 32.3%, 15.5%, 7.1%, 17.7%, and 7.2%, respectively. Nonparametric one-sided test revealed that patients treated with adjuvant CRT had significantly worse physical QOL, social-emotional QOL, and swallowing scores than patients treated with surgery alone (p = 0.01, p = 0.02, p = 0.03, respectively); that patients treated with surgery and adjuvant RT had significantly worse physical QOL and social-emotional QOL than patients treated with surgery alone (p < 0.01, p = 0.01, respectively) and that patients treated with surgery and adjuvant CRT had significantly worse swallowing and neck pain than patients treated with surgery and adjuvant RT (p = 0.03, p = 0.05, respectively).
In patients with surgically treated MPT, adjuvant CRT and RT were associated with worse PROMs.
4 Laryngoscope, 134:4549-4556, 2024.
本研究描述了接受恶性腮腺肿瘤（MPT）手术治疗的患者的患者报告结局测量（PROMs）和相关因素。
这是一项回顾性研究，纳入了多学科头颈部癌症（HNC）生存随访诊所（2017-2023 年）中所有接受手术治疗的 MPT 患者。PROMs 包括华盛顿大学生活质量问卷（UW-QOL）、进食评估工具（EAT-10）、患者健康问卷（PHQ-8）、广泛性焦虑症（GAD-7）、颈部残疾指数（NDI）和失眠严重程度指数。采用多变量回归分析探讨与 PROMs 相关的临床预测因素。
在 62 名 MPT 患者中，最后一次随访时出现临床相关吞咽困难症状（EAT-10）、抑郁症状升高（PHQ-8）、中度/重度焦虑症状（GAD-7）、日常生活中中度/重度颈部疼痛（NDI）和中度/重度失眠症状的患者比例分别为 32.3%、15.5%、7.1%、17.7%和 7.2%。非参数单侧检验显示，接受辅助 CRT 治疗的患者的生理 QOL、社会情感 QOL 和吞咽评分明显低于仅接受手术治疗的患者（p=0.01、p=0.02、p=0.03）；接受手术和辅助 RT 治疗的患者的生理 QOL 和社会情感 QOL 明显低于仅接受手术治疗的患者（p<0.01、p=0.01），接受手术和辅助 CRT 治疗的患者的吞咽和颈部疼痛明显差于接受手术和辅助 RT 治疗的患者（p=0.03、p=0.05）。
在接受手术治疗的 MPT 患者中，辅助 CRT 和 RT 与更差的 PROMs 相关。
4 级《喉镜》，134：4549-4556，2024。
